지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objective : This study was designed to investigate the possibility of AR for chronic renal injury.
Methods : The author first investigated the expression levels of DNA by inducing of chronic renal injury. Then, the author investigated the effects of AR on chronic renal injury induced by combination treatment with Adriamycin and cisplatin in terms of changes in body weights and renal tissues, urine volume, BUN and creatinine levels, creatinine clearance and histopathological changes in renal tissues. Total expression levels of 546 genes were elevated or lowered by induction of chronic renal injury. Genes of which whose expression levels were elevated by induction of chronic renal injury were related to the PPAR signaling pathway and fatty acid mechanism, etc. Genes of which expression levels were lowered by induction of chronic renal injury were related to the neuroactive ligand-receptor signaling pathway.
Results : Oral administration of AR restored renal mass which was reduced by induction of chronic renal injury. AR also restored creatinine clearance and lowered serum BUN level. In histopathological observation, the AR group has a tendency to prevent tissue damages as shown in the chronic renal injury group.
Conclusions : AR can be used to treat patients with chronic renal injury although further study will be needed to elucidate the exact mechanisms in the efficacy of AR on chronic renal injury.
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참고문헌 (29)
참고문헌 신청
Bergeron
Bertani T / 1986 / Adriamycin-induced glomerulosclerosis in the rat / Am J Kidney Dis. 7 (1) : 12 ~ 19
Borch RF / 1987 / The platinum antitumor drugs. In :Powis G, Prough RA, eds. Metabolism & Action of Anticancer Drugs / Taylor & Francis : 163 ~ 193
Florell SR / 2001 / Preservation of RNA for functional genomic studies: a multidisciplinary tumor bank protocol / Mod Pathol 14 (2) : 116 ~ 128
Goldstein RS / 1981 / cis-Dichlorodiammineplatinum nephrotoxicity: Time course and dose response of renal functional impairment / Toxicol Appl Pharmacol 60 : 163 ~ 175
Bertani T / 1986 / Adriamycin-induced glomerulosclerosis in the rat / Am J Kidney Dis. 7 (1) : 12 ~ 19
Borch RF / 1987 / The platinum antitumor drugs. In :Powis G, Prough RA, eds. Metabolism & Action of Anticancer Drugs / Taylor & Francis : 163 ~ 193
Florell SR / 2001 / Preservation of RNA for functional genomic studies: a multidisciplinary tumor bank protocol / Mod Pathol 14 (2) : 116 ~ 128
Goldstein RS / 1981 / cis-Dichlorodiammineplatinum nephrotoxicity: Time course and dose response of renal functional impairment / Toxicol Appl Pharmacol 60 : 163 ~ 175
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