지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Objectives : Sokmyeung-tang(SMT) has been used for treatment of CVA in traditional oriental medicine, so this study was designed to evaluate the effect of SMT's protection on brain cell damage against the oxidative stress that was affected by CVA, We also investigated the effect of motor function improvement and neurotrophic factor in ischemic cerebral damaged rats. Methods : We measured cell viability after administrating SMT, chemicals(Paraquat, SNP, rotenone, and H2O2) which cause oxidative stress, and both SMT and chemicals. We carried out neurobehavioral evaluation(Rotarod test, Beam-walking test, postural reflex test) and observed BDNF (brain-derived neurotrophic factor) expression by injecting SMT into ischemic cerebral damaged rat. Results : Through this study, we observed the following three results. First, brain cell death caused by paraquat, rotenone, and H2O2 significantly decreased with the treatment of SMT. Second, neuronal movement function in ischemic cerebral damaged rats was significantly improved by the treatment of SMT. Third, BDNF in ischemic cerebral damaged rats increased with the treatment of SMT. Conclusions : SMT protects brain cells from damage induced by oxidative stress (Paraquat, rotenone, H_2O_2). SMT also improves neuronal movement function and increases BDNF in ischemic cerebral damaged rats.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
/ 1986 / / Fridovich I. Adv. Enzymol : 58 ~
Balduini W / 2000 / Long-lasting behavioral alterations following a hypoxic ischemic brain injury in neonatal rats / Brain Research 895 : 318 ~ 325
Benvensite H / 1998 / Elevation of the extracellular concentrations of glutamate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysi
Choi DW / 1987 / Glutamate neurotoxicity in cortical cell culture / J Neurosci 7 : 357 ~ 368
Dyker AG / 1998 / Duration of neuroprotective treatment for ischemic stroke / Stroke 29 : 535 ~ 542
Balduini W / 2000 / Long-lasting behavioral alterations following a hypoxic ischemic brain injury in neonatal rats / Brain Research 895 : 318 ~ 325
Benvensite H / 1998 / Elevation of the extracellular concentrations of glutamate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysi
Choi DW / 1987 / Glutamate neurotoxicity in cortical cell culture / J Neurosci 7 : 357 ~ 368
Dyker AG / 1998 / Duration of neuroprotective treatment for ischemic stroke / Stroke 29 : 535 ~ 542
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