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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제47권 제6호
- 발행연도
- 2017.1
- 수록면
- 402 - 415 (14page)
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초록· 키워드
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Purpose: The aim of this study was to determine the effects of patterned human periodontal ligament stem cell (hPDLSC) sheets fabricated using a thermoresponsive substratum.
Methods: In this study, we fabricated patterned hPDLSC sheets using nanotopographical cues to modulate the alignment of the cell sheet.
Results: The hPDLSCs showed rapid monolayer formation on various surface pattern widths. Compared to cell sheets grown on flat surfaces, there were no significant differences in cell attachment and growth on the nanopatterned substratum. However, the patterned hPDLSC sheets showed higher periodontal ligamentogenesis-related gene expression in early stages than the unpatterned cell sheets.
Conclusions: This experiment confirmed that patterned cell sheets provide flexibility in designing hPDLSC sheets, and that these stem cell sheets may be candidates for application in periodontal regenerative therapy.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Seo BM / 2004 / Investigation of multipotent postnatal stem cells from human periodontal ligament / Lancet 364:149~155
Lemaitre M / 2017 / Periodontal tissue regeneration using syngeneic adipose-derived stromal cells in a mouse model / Stem Cells Transl Med 6:656~665
Wang ZS / 2016 / The use of platelet-rich fibrin combined with periodontal ligament and jaw bone mesenchymal stem cell sheets for periodontal tissue engineering / Sci Rep 6:28126
Feng R / 2013 / Application of stem cell technology in dental regenerative medicine / Adv Wound Care(New Rochelle) 2:296~305
Du J / 2014 / Allogeneic bone marrow mesenchymal stem cell transplantation for periodontal regeneration / J Dent Res 93:183~188
Lemaitre M / 2017 / Periodontal tissue regeneration using syngeneic adipose-derived stromal cells in a mouse model / Stem Cells Transl Med 6:656~665
Wang ZS / 2016 / The use of platelet-rich fibrin combined with periodontal ligament and jaw bone mesenchymal stem cell sheets for periodontal tissue engineering / Sci Rep 6:28126
Feng R / 2013 / Application of stem cell technology in dental regenerative medicine / Adv Wound Care(New Rochelle) 2:296~305
Du J / 2014 / Allogeneic bone marrow mesenchymal stem cell transplantation for periodontal regeneration / J Dent Res 93:183~188
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