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Purpose: Triphala is a combination of three medicinal plants, extensively used in Ayurvedasince ancient times. Triphala mouthwash is used in the treatment of periodontal diseasesbecause of its antimicrobial and antioxidant properties. The aim of this study is to comparethe efficacy of triphala mouthwash with 0.2% chlorhexidine in hospitalized periodontaldisease patients. Methods: In this double-blind, randomized, multicenter clinical trial, 120 patients wereequally divided into three groups. Patients in group A were advised to rinse their mouthswith 10 mL of distilled water, group B with 0.2% chlorhexidine, and group C with triphalamouthwash for 1 minute twice daily for two weeks. The plaque index (PI) and the gingivalindex (GI) were recorded on the first and the fifteenth day. Results: There was no significant difference when the efficacy of triphala was comparedwith 0.2% chlorhexidine in hospitalized patients with periodontal disease. However, a statisticallysignificant difference was observed in PI and GI when both group B and group Cwere compared with group A and also within groups B and C, after 15 days (P<0.05). Conclusions: The triphala mouthwash (herbal) is an effective antiplaque agent like 0.2%chlorhexidine. It is significantly useful in reducing plaque accumulation and gingival inflammation,thereby controlling periodontal diseases in every patient. It is also cost effective,easily available, and well tolerable with no reported side effects.

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