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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제44권 제1호
- 발행연도
- 2014.1
- 수록면
- 25 - 32 (8page)
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초록· 키워드
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Purpose: Periodontitis is an infectious disease caused predominantly by gram-negative anerobes.
The host inflammatory response to these bacteria causes alveolar bone loss that ischaracterized as periodontitis. Omega-3 fatty acids (ω-3 FAs) have anti-inflammatory properties,thus have been used to treat some chronic inflammatory diseases such as cardiovasculardisease and rheumatoid arthritis. We aimed to evaluate the effect of dietary supplementationwith ω-3 FAs as a host modulating agent in patients with chronic periodontitis.
Methods: Sixty otherwise healthy subjects with moderate and severe chronic periodontitiswere enrolled in our randomised, double-blind, placebo-controlled trial. The control group(CG, n=30) was treated with scaling and root planing (SRP) and given a placebo; thetreatment group (TG, n=30) was treated with SRP and dietary supplementation of ω-3FAs (one 300 mg tablet daily for 12 weeks). Periodontal clinical parameters and serum Creactiveprotein (CRP) levels were evaluated in all patients at baseline, a 6-week and 12-week period after treatment.
Results: A significant reduction in the gingival index, sulcus bleeding index, pocket depth,and clinical attachment level was found in the TG compared to the CG at a 12-week period.
However, no statistically significant changes in serum CRP levels were found.
Conclusions: Our findings suggest that ω-3 FAs can successfully reduce gingival inflammation,pocket depth, and attachment level gain. Dietary supplementation with ω-3 FAsmay have potential benefits as a host modulatory agent in the prevention and/or adjunctivemanagement of chronic periodontitis.
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참고문헌 (40)
참고문헌 신청
Marion-Letellier R / 2008 / Comparison of cytokine modulation by natural peroxisome proliferator-activated receptor gamma ligands with synthetic ligands in intestinal-like Caco-2 cells and human dendritic cells--potential for dietary modulation of peroxisome proliferator-activated receptor gamma in intestinal inflammation / Am J Clin Nutr 87:939~948
González-Periz A / 2009 / Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins / FASEB J 23:1946~1957
Hasturk H / 2007 / Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo / J Immunol 179:7021~7029
Alam SQ / 1991 / Arachidonic acid, prostaglandin E2 and leukotriene C4 levels in gingiva and submandibular salivary glands of rats fed diets containing n-3 fatty acids / Lipids 26:895~900
Campan P / 1997 / Pilot study on n-3 polyunsaturated fatty acids in the treatment of human experimental gingivitis / J Clin Periodontol 24:907~913
González-Periz A / 2009 / Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins / FASEB J 23:1946~1957
Hasturk H / 2007 / Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo / J Immunol 179:7021~7029
Alam SQ / 1991 / Arachidonic acid, prostaglandin E2 and leukotriene C4 levels in gingiva and submandibular salivary glands of rats fed diets containing n-3 fatty acids / Lipids 26:895~900
Campan P / 1997 / Pilot study on n-3 polyunsaturated fatty acids in the treatment of human experimental gingivitis / J Clin Periodontol 24:907~913
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