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학술저널
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대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제41권 제5호
발행연도
2011.1
수록면
227 - 233 (7page)

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Purpose: The aim of this study was to compare osteoblast behavior on zirconia and titanium under conditions cultured with bone morphogenetic protein-2. Methods: MC3T3-E1 cells were cultured on sandblasted zirconia and sandblasted/etched titanium discs. At 24 hours after seeding MC3T3-E1, the demineralized bone matrix (DBM) gel alone and the DBM gel with bone morphogenetic protein-2(BMP-2) were added to the culture medium. The surface topography was examined by confocal laser scanning microscopy. Cellular proliferation was measured at 1, 4, and 7 days after gel loading. Alkaline phosphatase activity was measured at 7 days after gel loading. The mRNA expression of ALPase, bone sialoprotein, type I collagen, runt-related transcription factor 2 (Runx-2),osteocalcin, and osterix were evaluated by real-time polymerase chain reaction at 4 days and 7 days. Results: At 1, 4, and 7 days after loading the DBM gel alone and the DBM gel with BMP-2, cellular proliferation on the zirconia and titanium discs was similar and that of the groups cultured with the DBM gel alone and the DBM gel with BMP-2 was not significantly different, except for titanium with BMP-2 gel. ALPase activity was higher in the cells cultured with BMP-2than in the other groups, but there was no difference between the zirconia and titanium. In ALPase, bone sialoprotein, osteocalcin,Runx-2 and osterix gene expression, that of cells on zirconia or titanium with BMP-2 gel was much more highly increased than titanium without gel at day 7. The gene expression level of cells cultured on zirconia with BMP-2 was higher than that on titanium with BMP-2 at day 7. Conclusions: The data in this study demonstrate that the osteoblastic cell attachment and proliferation of zirconia were comparable to those of titanium. With the stimulation of BMP-2, zirconia has a more pronounced effect on the proliferation and differentiation of the osteoblastic cells compared with titanium.
#Bone morphogenetic protein-2 #Cell differentiation #Cell proliferation #Zirconium oxide.

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참고문헌 (19)

참고문헌 신청
Akagawa Y / 1998 / Comparison between freestanding and tooth-connected partially stabilized zirconia implants after two years’ function in monkeys: a clinical and histologic google schola Albrektsson T / 2004 / Oral implant surfaces: Part 1--review focusing on topographic and chemical properties of different surfaces and in vivo responses to them / Int J Pros google schola Albrektsson T / 2004 / Oral implant surfaces: Part 2--review focusing on clinical knowledge of different surfaces / Int J Prosthodont 17 : 544 ~ 564 google schola Bachle M / 2007 / Behavior of CAL72 osteoblast-like cells cultured on zirconia ceramics with different surface topographies / Clin Oral Implants Res 18 : 53 ~ 59 google schola Chevalier J / 2006 / What future for zirconia as a biomaterial / Biomaterials 27 : 535 ~ 543 google schola

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