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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치과보철학회 The Journal of Advanced of Prosthodontics The Journal of Advanced of Prosthodontics 제6권 제4호
- 발행연도
- 2014.1
- 수록면
- 285 - 294 (10page)
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PURPOSE. The purpose of this study was to evaluate the properties of a porous zirconia scaffold coated with bioactive materials and compare the in vitro cellular behavior of MC3T3-E1 preosteoblastic cells to titanium and zirconia disks and porous zirconia scaffolds. MATERIALS AND METHODS. Titanium and zirconia disks were prepared. A porous zirconia scaffold was fabricated with an open cell polyurethane disk foam template. The porous zirconia scaffolds were coated with β-TCP, HA and a compound of β-TCP and HA (BCP). The characteristics of the specimens were evaluated using scanning electron microscopy (SEM), energy dispersive x-ray spectrometer (EDX), and x-ray diffractometry (XRD). The dissolution tests were analyzed by an inductively coupled plasma spectrometer (ICP). The osteogenic effect of MC3T3-E1 cells was assessed via cell counting and reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS. The EDX profiles showed the substrate of zirconia, which was surrounded by the Ca-P layer. In the dissolution test, dissolved Ca2+ ions were observed in the following decreasing order; β-TCP > BCP > HA (P<.05). In the cellular experiments, the cell proliferation on titanium disks appeared significantly lower in comparison to the other groups after 5 days (P<.05). The zirconia scaffolds had greater values than the zirconia disks (P<.05). The mRNA level of osteocalcin was highest on the non-coated zirconia scaffolds after 7 days. CONCLUSION. Zirconia had greater osteoblast cell activity than titanium. The interconnecting pores of the zirconia scaffolds showed enhanced proliferation and cell differentiation. The activity of osteoblast was more affected by microstructure than by coating materials.
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참고문헌 (36)
참고문헌 신청
Wohlfahrt JC. / 2012 / Porous titanium granules in the surgical treatment of peri-implant osseous defects : a randomized clinical trial / Int J Oral Maxillofac Implants 27:401~410
Steinemann SG. / 1998 / Titanium--the material of choice? / Periodontol 2000 17:7~21
Langhoff JD. / 2008 / Comparison of chemically and pharmaceutically modified titanium and zirconia implant surfaces in dentistry : a study in sheep / Int J Oral Maxillofac Surg 37:1125~1132
Itälä AI. / 2001 / Pore diameter of more than 100 microm is not requisite for bone ingrowth in rabbits / J Biomed Mater Res 58:679~683
Aboushelib MN. / 2013 / Influence of surface nano-roughness on osseointegration of zirconia implants in rabbit femur heads using selective infiltration etching technique / J Oral Implantol 39:583~590
Steinemann SG. / 1998 / Titanium--the material of choice? / Periodontol 2000 17:7~21
Langhoff JD. / 2008 / Comparison of chemically and pharmaceutically modified titanium and zirconia implant surfaces in dentistry : a study in sheep / Int J Oral Maxillofac Surg 37:1125~1132
Itälä AI. / 2001 / Pore diameter of more than 100 microm is not requisite for bone ingrowth in rabbits / J Biomed Mater Res 58:679~683
Aboushelib MN. / 2013 / Influence of surface nano-roughness on osseointegration of zirconia implants in rabbit femur heads using selective infiltration etching technique / J Oral Implantol 39:583~590
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