지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제6권 제1호
- 발행연도
- 2008.1
- 수록면
- 11 - 18 (8page)
이용수
초록· 키워드
오류제보하기
Objective：Lithium has been used as a mood stabilizer for more than 50 years since its first use in the treatment of bipolar disorder. However, the mechanisms of its therapeutic actions remain unclear. Previous studies have shown neuroprotective and stress-attenuating effects of lithium which are thought to be related to its therapeutic actions. This article reviewed neuroprotective and stress-attenuating effects of lithium by searching data from previous studies.
Methods：The literature on neuroprotective and stress-attenuating effects of lithium was searched using PubMed.
Results：Lithium has the ability to protect neurons against a variety of insults. Lithium has been shown to prevent or attenuate the altered neural plasticity induced by stress at the molecular, structural, and behavioral levels, at least in animal studies. Neuroprotective effects of lithium have also been demonstrated in patients with bipolar disorder. The neuroprotective mechanisms of lithium include up-regulation of cytoprotective proteins, such as bcl-2, direct and indirect inhibition of glycogen synthase kinase 3-β, down-regulation of pro-apoptotic proteins, such as p38 and Bax, and activation of cAMP response element binding protein, with the resulting up-regulation of neurotrophic factors, such as brain-derived neurotrophic factor.
Conclusion：These neuroprotective and stress-attenuating effects may contribute to the therapeutic actions of lithium.
목차
등록된 정보가 없습니다.
참고문헌 (48)
참고문헌 신청
Hashimoto R / 2002 / Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation / J Neurochem 80:589~597
Hashimoto R / 2003 / Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl- D-aspartate receptor-mediated excitotoxicity / FEBS Lett 538:145~148
Chalecka-Franaszek E / 1999 / Lithium activates the serine/ threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons / Proc Natl Acad Sci U S A :8745~8750
Chen RW / 1999 / Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity / J Biol Chem 274:6039~6042
Lu R / 1999 / Lithium attenuates p53 levels in human neuroblastoma SH-SY5Y cells / Neuroreport 10:1123~1125
Hashimoto R / 2003 / Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl- D-aspartate receptor-mediated excitotoxicity / FEBS Lett 538:145~148
Chalecka-Franaszek E / 1999 / Lithium activates the serine/ threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons / Proc Natl Acad Sci U S A :8745~8750
Chen RW / 1999 / Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity / J Biol Chem 274:6039~6042
Lu R / 1999 / Lithium attenuates p53 levels in human neuroblastoma SH-SY5Y cells / Neuroreport 10:1123~1125
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