지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제13권 제2호
- 발행연도
- 2015.1
- 수록면
- 157 - 162 (6page)
이용수
초록· 키워드
오류제보하기
Objective: This study examined the utility of adenine for preventing clozapine-induced neutropenia.
Methods: This retrospective study examined the effect of adenine on clozapine-induced neutropenia in patients with treatment- resistant schizophrenia and was conducted at Okehazama Hospital in Japan from July 2010 to June 2013. Adenine was available for use from June 2011 onwards. Twenty-one patients started receiving clozapine treatment from July 2010 to April 2011 (the pre-adenine adoption group), and 47 patients started receiving it from May 2011 to June 2013 (the post-adenine adoption group). The effects of adenine were assessed based on changes in the patients’ leukocyte counts and the frequency of treatment discontinuation due to clozapine-induced neutropenia.
Results: Sixty-eight patients were treated with clozapine from July 2010 to June 2013. Of the 21 patients in the pre-adenine adoption group, 4 discontinued treatment due to clozapine-induced neutropenia, whereas only 2 of the 47 patients in the post-adenine adoption group discontinued treatment. The frequency of treatment discontinuation due to clozapine-induced neutropenia was significantly lower in post-adenine adoption group than in the pre-adenine adoption group (p=0.047).
Conclusion: Adenine decreased the frequency of treatment discontinuation due to clozapine-induced neutropenia. Our data suggest that combined treatment with clozapine and adenine is a safe and effective strategy against treatment-resistant schizophrenia.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Alvir JM. / 1993 / Clozapine-induced agranulocytosis. Incidence and risk factors in the United States / N Engl J Med 329 : 162 ~ 167
Alvir JM. / 1994 / Agranulocytosis: incidence and risk factors / J Clin Psychiatry 55 (Suppl B) : 137 ~ 138
Bender S. / 2004 / Safety and efficacy of combined clozapinelithium pharmacotherapy / Int J Neuropsychopharmacol 7 : 59 ~ 63
Dennison U. / 2011 / The incidence and clinical correlates of lithium toxicity : a retrospective review / Ir J Med Sci 180 : 661 ~ 665
Hummer M. / 1994 / Clozapine-induced transient white blood count disorders / J Clin Psychiatry 55 : 429 ~ 432
Alvir JM. / 1994 / Agranulocytosis: incidence and risk factors / J Clin Psychiatry 55 (Suppl B) : 137 ~ 138
Bender S. / 2004 / Safety and efficacy of combined clozapinelithium pharmacotherapy / Int J Neuropsychopharmacol 7 : 59 ~ 63
Dennison U. / 2011 / The incidence and clinical correlates of lithium toxicity : a retrospective review / Ir J Med Sci 180 : 661 ~ 665
Hummer M. / 1994 / Clozapine-induced transient white blood count disorders / J Clin Psychiatry 55 : 429 ~ 432
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Adenine attenuates lipopolysaccharide-induced inflammatory reactions
The Korean Journal of Physiology & Pharmacology
2018 .07
-
Efficacy of Adenine in the Treatment of Leukopenia and Neutropenia Associated with an Overdose of Antipsychotics or Discontinuation of Lithium Carbonate Administration: Three Case Studies
Clinical Psychopharmacology and Neuroscience
2016 .01
-
Prevalence and Risk Factors Associated with Neutropenia in Hospitalized Patients with Systemic Lupus Erythematosus
대한류마티스학회지
2017 .01
-
Exploring the intersection of laser technology and neutropenia: mechanisms, impacts, and mitigation strategies
MEDICAL LASERS
2024 .06
-
Adenine Inhibits B16-F10 Melanoma Cell Proliferation
대한의생명과학회지
2020 .09
-
Neutropenia during the First Cycle of Induction Chemotherapy Is Prognostic for Poor Survival in Locoregionally Advanced Nasopharyngeal Carcinoma: A Real-World Study in an Endemic Area
Cancer Research and Treatment
2018 .01
-
비호지킨림프종 환자의 발열성 호중구감소증에 대한 페그필그라스팀의 예방효과
한국임상약학회지
2015 .01
-
Extensive gingival necrosis and sequestration of the alveolar bone caused by methimazole-induced neutropenia and three-year follow-up
Journal of Periodontal & Implant Science
2015 .01
-
Which One is More Effective, Filgrastim or Lenograstim, During Febrile Neutropenia Attack in Hospitalized Patients with Solid Tumors?
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Acute cholecystitis in neutropenic patients
Annals of Hepato-Biliary-Pancreatic Surgery
2019 .08
-
항암화학치료 후 발생한 호중구 감소증에 대한 사물탕가감방 증례 보고
동의생리병리학회지
2015 .02
-
항암화학치료 후 발생한 호중구 감소증에 대한 사물탕가감방 증례 보고
동의생리병리학회지
2015 .01
-
Improvement of neutropenia in 2 adolescent cases treated with empagliflozin for glycogen storage disease type Ib
대한소아응급의학회지
2024 .07
-
Clinical Study on Safety and Efficacy of JiSaiXin (Recombinant Human Granulocyte Colony Stimulating Factor Injection Manufactured in China) for Chinese Undergoing Chemotherapy
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone
Clinical Psychopharmacology and Neuroscience
2017 .01
-
APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia
Cancer Research and Treatment
2018 .01
-
Adenine Induces Apoptosis Markers in B16-F10 Melanoma Cells: Inhibiting Akt and mTOR and Increasing Bax/Bcl-2 Ratio
대한의생명과학회지
2023 .09
-
A Patient with Neutropenia and Splenomegaly: A Case Report from Department of Family Medicine in Tertiary Hospital Center
Korean Journal of Family Medicine
2021 .01
-
Influence of Residential Environment and Lifestyle on Multiple Primary Malignancies in Taiwan
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Clinical impact of mitomycin-C induced neutropenia after hyperthermic intraperitoneal chemotherapy with cytoreductive surgery in colorectal cancer patients
대한외과학회 학술대회 초록집
2019 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0