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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제13권 제2호
- 발행연도
- 2015.1
- 수록면
- 168 - 173 (6page)
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초록· 키워드
오류제보하기
Objective: We examined the difference in responses to donepezil between carriers and non-carriers of the A allele at the +4 position of the choline acetyltransferase (ChAT) gene in Koreans.
Methods: Patients who met the criteria for probable Alzheimer’s disease (AD) (n=199) were recruited. Among these, 145 completed the 12-week follow-up evaluation and 135 completed the 26-week scheduled course. Differences and changes in the Korean version of the mini-mental state examination (MMSE-KC) score, Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Assessment Battery (CERAD-K[N]) wordlist subtest score (WSS), CERAD-K(N) total score (TS), and the Korean version of geriatric depression scale (GDS-K) score between baseline and 12 weeks or 26 weeks were assessed by the Student’s t-test.
Results: At 12 weeks, the changes in the MMSE-KC score, CERAD-K(N) WSS, and CERAD-K(N) TS from baseline were not significant between ChAT A allele carriers and non-carriers; however, at 26 weeks, these changes were significantly larger in ChAT A allele carriers than in non-carriers (p=0.02 for MMSE-KC and p=0.03 for CERAD-K(N) WSS respectively).
Conclusion: Our findings in this study suggested that presence of the A allele at the +4 position of ChAT might positively influence the treatment effect of donepezil in the early stages of AD in Koreans.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Ahn Jo S. / 2006 / ApoE-epsilon 4-dependent association of the choline acetyltransferase gene polymorphisms(2384G>A and 1882G>A)with Alzheimer's disease / Clin Chim Ac
Birks J. / 2006 / Cholinesterase inhibitors for Alzheimer's disease / Cochrane Database Syst Rev (1) : CD005593 ~
Bizzarro A. / 2005 / Apolipoprotein E epsilon4 allele differentiates the clinical response to donepezil in Alzheimer's disease / Dement Geriatr Cogn Disord 20 : 254 ~ 261
Cacabelos R. / 2012 / Pharmacogenomic protocols in CNS disorders Cacabelos R, Martinez R, Fernandez-Novoa L, Carril JC, Lombardi V, Carrera I, et al. Genomics of Dementia : A
Choi SH. / 2008 / Effect of ApoE genotype on response to donepezil in patients with Alzheimer's disease / Dement Geriatr Cogn Disord 25 : 445 ~ 450
Birks J. / 2006 / Cholinesterase inhibitors for Alzheimer's disease / Cochrane Database Syst Rev (1) : CD005593 ~
Bizzarro A. / 2005 / Apolipoprotein E epsilon4 allele differentiates the clinical response to donepezil in Alzheimer's disease / Dement Geriatr Cogn Disord 20 : 254 ~ 261
Cacabelos R. / 2012 / Pharmacogenomic protocols in CNS disorders Cacabelos R, Martinez R, Fernandez-Novoa L, Carril JC, Lombardi V, Carrera I, et al. Genomics of Dementia : A
Choi SH. / 2008 / Effect of ApoE genotype on response to donepezil in patients with Alzheimer's disease / Dement Geriatr Cogn Disord 25 : 445 ~ 450
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