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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제9권 제1호
- 발행연도
- 2011.1
- 수록면
- 9 - 16 (8page)
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초록· 키워드
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In conventional pharmacological research in the field of mental disorders, pharmacological effect and dose have been estimated by ethological approach and in vitro data of affinity to the site of action. In addition, the frequency of administration has been estimated from drug kinetics in blood. However, there is a problem regarding an objective index of drug effects in the living body. Furthermore, the possibility that the concentration of drug in blood does not necessarily reflect the drug kinetics in target organs has been pointed out. Positron emission tomography (PET) techniques have made progress for more than 20 years,and made it possible to measure the distribution and kinetics of small molecule components in living brain. In this article, we focused on rational drug dosing using receptor occupancy and proof-of-concept of drugs in the drug development process using PET.
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참고문헌 (50)
참고문헌 신청
Nordström AL / 1998 / Plasma prolactin and central D2 receptor occupancy in antipsychotic drug-treated patients / J Clin Psychopharmacol 18:305~310
Bressan RA / 2004 / Prolactinemia is uncoupled from central D2/D3 dopamine receptor occupancy in amisulpride treated patients / Psychopharmacology (Berl) 175:367~373
Arakawa R / 2010 / PET measurement of dopamine D2 receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemia / J Clin Psychiatry 71:1131~1137
Meyer JH / 2004 / Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study / Am J Psychiatry 161:826~835
Suhara T / 2003 / High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography / Arch Gen Psychiatry 60:386~391
Bressan RA / 2004 / Prolactinemia is uncoupled from central D2/D3 dopamine receptor occupancy in amisulpride treated patients / Psychopharmacology (Berl) 175:367~373
Arakawa R / 2010 / PET measurement of dopamine D2 receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemia / J Clin Psychiatry 71:1131~1137
Meyer JH / 2004 / Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study / Am J Psychiatry 161:826~835
Suhara T / 2003 / High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography / Arch Gen Psychiatry 60:386~391
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