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학술저널
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대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제8권 제2호
발행연도
2010.1
수록면
79 - 83 (5page)

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Recently, Thai psychiatrists have increased their attention to metabolic abnormalities among patients receiving antipsychotics,especially a condition called metabolic syndrome (MetS). Therefore, the objectives of this paper were to review the rate of MetS associated with antipsychotics, to compare the prevalence of MetS between those receiving first and second generation antipsychotics (FGAs, SGAs) and to find the associated factors of MetS in Thai patients. Reviewing of the PUBMED database and two Thai journals was conducted. Authors interested in this topic were also contacted. The inclusion and exclusion criteria were defined and finally, 4 papers that fulfilled the criteria were reviewed. It was found that the prevalence rate of MetS in Thai patients varied from 15.4% to 23.9% by the IDF criteria and it was higher, between 20.5% to 30.5%, by the updated ATP III criteria. The incidence rate, by the IDF criteria, in patients who took any type of antipsychotic for one year was 20%. The prevalence rate of MetS, by the IDF criteria, among those receiving FGAs and SGAs was 9.4% to 27.1% and 20% to 20.3%, respectively. Difference in rates of MetS was found in different regions of Thailand. The factors associated with MetS were the use of SGAs and a family history of hypertension. The prevalence rate of MetS in Thai psychiatric patients was rather lower than that from a study in Taiwan. The definition of MetS according to IDF is less likely to identify metabolically abnormal but non-obese individuals. Perhaps, the modified or updated ATP III criteria is more appropriate to detect MetS in Asian patients, particularly those in Thailand.
#Metabolic syndrome #Antipsychotics #Psychiatric patients #Thailand.

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참고문헌 (23)

참고문헌 신청
Allison DB / 1999 / Cappelleri JC, Infante MC, et al. Antipsychotic-induced weight gain: a comprehensive research synthesis / Am J Psychiatry 156 : 1686 ~ 1696 google schola Ananth J / 2004 / Atypical antipsychotic induced weight gain: pathophysiology and management / Ann Clin Psychiatry 16 : 75 ~ 85 google schola Bai YM / 2007 / Adinopectin as a potent biomarker for the metabolic syndrome in Chinese patients taking clozapine for schizophrenia / J Clin Pychiatry 68 : 1834 ~ 1839 google schola Boonyavarakul A / 2005 / Prevalence of the metabolic syndrome and its association factors between percentage body fat and body mass index in rural Thai population aged 35 ye google schola Cameron AJ / 2004 / The metabolic syndrome: prevalence in worldwide populations / Endocrinol Metab Clin North Am 33 : 351 ~ 375 google schola

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