지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제15권 제4호
- 발행연도
- 2017.1
- 수록면
- 343 - 351 (9page)
이용수
초록· 키워드
오류제보하기
Objective: Impulsivity is a core feature of borderline personality disorder (BPD) and antisocial personality disorder (ASPD) that likely arises from combined genetic and environmental influences. The interaction of the low activity variant of the monoamine oxidase-A (MAOA-L) gene and early childhood adversity has been shown to predict aggression in clinical and non-clinical populations. Although impulsivity is a risk factor for aggression in BPD and ASPD, little research has investigated potential gene-environment (G×E) influences impacting its expression in these conditions. Moreover, G×E interactions may differ by diagnosis. Methods: Full factorial analysis of variance was employed to investigate the influence of monoamine oxidase-A (MAO-A) genotype, childhood abuse, and diagnosis on Barratt Impulsiveness Scale-11 (BIS-11) scores in 61 individuals: 20 subjects with BPD, 18 subjects with ASPD, and 23 healthy controls. Results: A group×genotype×abuse interaction was present ( F (2,49)=4.4, p =0.018), such that the interaction of MAOA-L and childhood abuse predicted greater BIS-11 motor impulsiveness in BPD. Additionally, BPD subjects reported higher BIS-11 attentional impulsiveness versus ASPD participants ( t (1,36)=2.3, p =0.025). Conclusion: These preliminary results suggest that MAOA-L may modulate the impact of childhood abuse on impulsivity in BPD. Results additionally indicate that impulsiveness may be expressed differently in BPD and ASPD.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Berlin HA / 2005 / Borderline personality disorder, impulsivity, and the orbitofrontal cortex / Am J Psychiatry 162 : 2360 ~ 2373
Blackburn R / 1998 / Psychopathy and the dimensions of personality disorder in violent offenders / Pers Indiv Differ 25 : 129 ~ 145
Brodsky BS / 1997 / Characteristics of borderline personality disorder associated with suicidal behavior / Am J Psychiatry 154 : 1715 ~ 1719
Chesin MS / 2010 / Pathways to high-lethality suicide attempts in individuals with borderline personality disorder / Arch Suicide Res 14 : 342 ~ 362
Dalley JW / 2011 / Impulsivity, compulsivity, and top-down cognitive control / Neuron 69 : 680 ~ 694
Blackburn R / 1998 / Psychopathy and the dimensions of personality disorder in violent offenders / Pers Indiv Differ 25 : 129 ~ 145
Brodsky BS / 1997 / Characteristics of borderline personality disorder associated with suicidal behavior / Am J Psychiatry 154 : 1715 ~ 1719
Chesin MS / 2010 / Pathways to high-lethality suicide attempts in individuals with borderline personality disorder / Arch Suicide Res 14 : 342 ~ 362
Dalley JW / 2011 / Impulsivity, compulsivity, and top-down cognitive control / Neuron 69 : 680 ~ 694
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