지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제10권 제3호
- 발행연도
- 2012.1
- 수록면
- 155 - 162 (8page)
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초록· 키워드
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Objective: The anti-apoptotic protein Bax inhibitor-1 (BI-1) is a regulator of apoptosis linked to endoplasmic reticulum (ER)stress, and BI-1－/－ mice exhibit increased sensitivity to tissue damage. The purpose of this study was to investigate the role of BI-1 in the pathogenesis of chronic mild stress (CMS)-induced depression-like behaviors in BI-1－/－ mice.
Methods: We delivered CMS for 2 or 6 weeks in BI-1-knockout and wild-type mice. Control groups of BI-1-knockout and wild-type mice were left undisturbed. The measured parameters were sucrose consumption at weeks 1, 2, 3, 4, 5, and 6, spontaneous locomotion, and a forced swimming test (FST) at weeks 2 and 6.
Results: Significant decreases in sucrose consumption and increases in immobility time in the FST were observed in both stress groups compared with the non-stress groups. Interestingly, at week 2, but not at week 6, BI-1－/－-stress mice showed less sucrose intake and greater immobility time than did BI-1＋/＋-stress mice.
Conclusion: These results suggest that BI-1 may play role in protecting against the depressogenic effects of CMS in the short term, but not in the long term. Further study is required to deepen understanding of the role of BI-1 in protecting against depression.
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참고문헌 (29)
참고문헌 신청
D'Aquila P / 1997 / Anti-anhedonic actions of the novel serotonergic agent flibanserin, a potential rapidly-acting antidepressant / Eur J Pharmacol 340:121~132
Dang H / 2009 / Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression / Prog Neuropsychopharmacol Biol Psychiatry 33:1417~1424
Grippo AJ / 2003 / Behavioral and cardiovascular changes in the chronic mild stress model of depression / Physiol Behav 78:703~710
D'aquila PS / 2000 / Exploratory behaviour and grooming after repeated restraint and chronic mild stress: effect of desipramine / Eur J Pharmacol 399:43~47
Harris RB / 1997 / Failure to change exploration or saccharin preference in rats exposed to chronic mild stress / Physiol Behav 63:91~100
Dang H / 2009 / Antidepressant effects of ginseng total saponins in the forced swimming test and chronic mild stress models of depression / Prog Neuropsychopharmacol Biol Psychiatry 33:1417~1424
Grippo AJ / 2003 / Behavioral and cardiovascular changes in the chronic mild stress model of depression / Physiol Behav 78:703~710
D'aquila PS / 2000 / Exploratory behaviour and grooming after repeated restraint and chronic mild stress: effect of desipramine / Eur J Pharmacol 399:43~47
Harris RB / 1997 / Failure to change exploration or saccharin preference in rats exposed to chronic mild stress / Physiol Behav 63:91~100
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