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자료유형
학술저널
저자정보
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대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제12권 제2호
발행연도
2014.1
수록면
157 - 159 (3page)

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Major depressive disorder and bipolar disorders are among the commonest neuropsychiatric conditions, affecting persons ofboth sexes which belong to all age groups. Comorbidity is the rule rather than the exception; anxiety spectrum disorders, somatoformdisorders, eating disorders and substance use disorders frequently co-exist with mood disorders. Catatonia is a seriouscomplication of the latter and every patient with a severe affective exacerbation should be assessed for the presence of catatonicsigns and symptoms. In a significant minority of patients, symptoms show treatment resistance; many patients experience severehopelessness and suicidal ideation, causing high rates of morbidity and mortality in afflicted individuals. Pharmacological managementis challenging and currently available psychotropic agents often fall short of inducing remission. Second generationantipsychotics have been shown in a number of studies as having an antidepressant and mood stabilizing effect. Aripiprazoleis a novel antipsychotic which is being increasingly used in difficult to treat mood disorders patients. Several controlled anduncontrolled studies have shown the efficacy and safety of this medication in subjects of all ages. Here a case series of threepatients is presented who suffered from refractory mood disorders but responded to aripiprazole with complete remission ofaffective symptoms.

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