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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제12권 제1호
- 발행연도
- 2014.1
- 수록면
- 37 - 40 (4page)
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초록· 키워드
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Objective: We investigated the effects of duloxetine on the plasma levels of catecholamine metabolites and serum brain-derivedneurotrophic factor (BDNF) in 64 patients with major depressive disorder (MDD).
Methods: Major depressive episode was diagnosed using the Structured Clinical Interview for the Diagnostic and StatisticalManual of Mental Disorders-fourth edition (DSM-IV) according to the DSM-IV text revision (DSM-IV-TR) criteria. The severityof depression was evaluated using the 17-item Hamilton Rating Scale for Depression (HAMD-17). Blood sampling and clinicalevaluation were performed on days 0, 28, and 56.
Results: Duloxetine treatment for 8 weeks significantly increased the plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levelsbut not the homovanillic acid (HVA) levels in responders with MDD.
Conclusion: These results imply that noradrenaline plays an important role in alleviating depressive symptoms.
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참고문헌 (8)
참고문헌 신청
Bocchio-Chiavetto L / 2010 / Serum and plasma BDNF levels in major depression: a replication study and metaanalyses / World J Biol Psychiatry 11 : 763 ~ 773
Chalon SA / 2003 / Duloxetine increases serotonin and norepinephrine availability in healthy subjects: a double-blind, controlled study / Neuropsychopharmacology 28 : 1685 ~
Fernandes BS / 2011 / Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis / J Psychiat
Katsuki A / 2012 / Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites, and response to mirtazapine
Pergolizzi JV Jr / 2013 / A review of duloxetine 60 mg once-daily dosing for the management of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal
Chalon SA / 2003 / Duloxetine increases serotonin and norepinephrine availability in healthy subjects: a double-blind, controlled study / Neuropsychopharmacology 28 : 1685 ~
Fernandes BS / 2011 / Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis / J Psychiat
Katsuki A / 2012 / Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites, and response to mirtazapine
Pergolizzi JV Jr / 2013 / A review of duloxetine 60 mg once-daily dosing for the management of diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal
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