지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 147 - 152 (6page)
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초록· 키워드
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Background: Iron deficiency anemia (IDA) is the most common anemia followed by anemia of chronic disease (ACD). Reticulocyte indices have been shown to be helpful indicators for detecting IDA. We investigated whether RBC and reticulocyte indices can be used to differentiate ACD from IDA.
Methods: A total of 85 women showing microcytic hypochromic anemia (38 IDA and 47 ACD cases) were enrolled. IDA was defined as those with ferritin level of <6 μg/dL and total iron binding capacity (TIBC) of >450 μg/dL. ACD was defined as ferritin level of ≥6 μg/dL, TIBC of ≤450 μg/dL, and presence of underlying diseases. We measured complete blood count, TIBC, iron, ferritin, and RBC and reticulocyte indices. The mean values of each item were compared between the two groups and sensitivity and specificity of each item in the differential diagnosis of ACD from IDA were determined by ROC curve analysis.
Results: In ACD, most of the RBC and reticulocyte indices were significantly higher than in IDA: mean cell volume (MCV), mean cell hemoglobin (MCH), mean cell hemoglobin concentration (MCHC), cellular hemoglobin concentration mean (CHCM), cellular hemoglobin content (CH), red cell distribution width (RDW), reticulocyte hemoglobin content (CHr), and mature RBC cellular hemoglobin content (CHm). All these indices, except MCV showed significant correlations with ferritin and/or TIBC. CHr level of ≥24.6 pg could be used to differentiate ACD from IDA with 85.1%sensitivity and 81.6% specificity.
Conclusions: The reticulocyte indices, especially CHr, are useful for the differential diagnosis of microcytic hypochromic anemias, ACD and IDA.
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참고문헌 (20)
참고문헌 신청
Bakr AF / 2006 / Measurement of reticulocyte hemoglobin content to diagnose iron deficiency in Saudi children / Eur J Pediatr 165 : 442 ~ 445
Brugnara C / 1997 / Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity / Am J Clin Pathol 108 : 133 ~ 142
Cavill I / 2006 / Iron and the anaemia of chronic disease: a review and strategic recommendations / Curr Med Red Opin 22 : 731 ~ 737
Ceylan C / 2007 / Evaluation of reticulocyte parameters in iron deficiency, vitamin B(12) deficiency and β-thalassemia minor patients / Int J Lab Hematol 29 : 327 ~ 334
De Benoist B / 2008 / Worldwide prevalence of anaemia 1993?2005, WHO global database on anemia / World Health Organization
Brugnara C / 1997 / Reticulocyte hemoglobin: an integrated parameter for evaluation of erythropoietic activity / Am J Clin Pathol 108 : 133 ~ 142
Cavill I / 2006 / Iron and the anaemia of chronic disease: a review and strategic recommendations / Curr Med Red Opin 22 : 731 ~ 737
Ceylan C / 2007 / Evaluation of reticulocyte parameters in iron deficiency, vitamin B(12) deficiency and β-thalassemia minor patients / Int J Lab Hematol 29 : 327 ~ 334
De Benoist B / 2008 / Worldwide prevalence of anaemia 1993?2005, WHO global database on anemia / World Health Organization
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