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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 194 - 198 (5page)
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초록· 키워드
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Natural killer (NK) cell neoplasms are a group of rare but highly malignant tumors. We report here one case of NK cell leukemia. A 54-yr-old woman presented with a 2-month history of progressive left neck mass. Based on the positive result of tissue PCR for Mycobacterium tuberculosis, she was
at first diagnosed with tuberculous lymphadenopathy. After two weeks, she developed generalized lymphadenopathy, hepatosplenomegaly, fever and anemia. Subsequent evaluation was performed including bone marrow aspiration and biopsy. Peripheral blood smear showed leukoerythroblastic
features with 31% blasts. Bone marrow was packed with agranular blastoid cells, which were periodic acid-Schiff (PAS) positive and myeloperoxidase (MPO) negative. Immunophenotyping showed that these cells were positive for CD45 and HLA-DR, whereas negative for CD3, CD5, CD7, CD10, CD13,
CD14, CD19, CD20, CD22, CD33, CD34, and CD61. Because of the absence of the markers of T-cell, B-cell, and myeloid lineage-specific antigens, we added CD16/56 for the immunophenotyping and the blasts were positive (94%). The tumor cells of biopsied lymph node were only positive for CD56,
consistent with NK cell lymphoma. Epstein-Barr virus (EBV) was not detected by RNA in situ hybridization. Culture for M. tuberculosis was negative. Thus this patient was diagnosed with blastic NK cell lymphoma/leukemia involving bone marrow and lymph node.
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등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Chan JK / 2001 / Aggressive NK-cell leukemia, in World Health Organization Classification of Tumours: Pathology and genetics of tumours of hematopoietic and lymphoid tissue / IARC Press
Chan JK / 2001 / Extranodal NK/T-cell lymphoma, nasal type, in World Health Organization Classification of Tumours: Pathology and genetics of tumours of hematopoietic and lymphoid tissue
Freud AG / 2006 / Human natural killer cell development / Immunol Rev 214 : 56 ~ 72
Goel MM / 2001 / Polymerase chain reaction vs. conventional diagnosis in fine needle aspirates of tuberculous lymph nodes / Acta Cytol 45 : 333 ~ 340
Jaffe ES / 2001 / Mature T-cell and NK-cell neoplasms: introduction, in World Health Organization Classification of Tumours: Pathology and genetics of tumours of hematopoietic and lympho
Chan JK / 2001 / Extranodal NK/T-cell lymphoma, nasal type, in World Health Organization Classification of Tumours: Pathology and genetics of tumours of hematopoietic and lymphoid tissue
Freud AG / 2006 / Human natural killer cell development / Immunol Rev 214 : 56 ~ 72
Goel MM / 2001 / Polymerase chain reaction vs. conventional diagnosis in fine needle aspirates of tuberculous lymph nodes / Acta Cytol 45 : 333 ~ 340
Jaffe ES / 2001 / Mature T-cell and NK-cell neoplasms: introduction, in World Health Organization Classification of Tumours: Pathology and genetics of tumours of hematopoietic and lympho
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