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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 636 - 640 (5page)
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초록· 키워드
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Objective To investigate the eff ect of botulinum toxin type A (BTXA) on drooling and the morphologic change of the salivary gland in patients with cerebral palsy.
Method Eight cerebral palsy patients suffering from severe drooling participated in this study. BTXA was injected into both submandibular and parotid glands under intravenous sedation and with ultrasound guidance (1 unit/gland/kg: maximum 100 units) in an outpatient or inpatient procedure. The severity of drooling was measured before injection and 3 weeks after injection using the Teacher Drooling Scale, the Drooling Score-severity,frequency and the Visual Analog Scale. To investigate the morphologic change of the salivary glands, the size of salivary glands were measured before injection and 3 weeks after injection using computed tomography of the neck. The measurement values were analyzed by Wilcoxon signed rank test.
Results Statistically significant improvements were shown in all three parameters for assessing the severity of drooling after BTXA injections (p<0.05). Size of the salivary glands were signifi cantly decreased at 3 weeks after BTXA injection (p<0.05).
Conclusion Salivary gland injection with BTXA could be a useful treatment method to reduce drooling in patients with cerebral palsy and decreased size of salivary glands may partially explain the mechanism.
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참고문헌 (22)
참고문헌 신청
Bachrach SJ / 1998 / Use of glycopyrrolate and other anticholinergic medication for sialorrhea in children with cerebral palsy / Clin Pediatr 37 : 485 ~ 490
Banerjee KJ / 2006 / Parotid and submandibular botulinum toxin A injections for sialorrhoea in children with cerebral palsy / Dev Med Child Neurol 48 : 883 ~ 887
Bhatia KP / 1999 / Botulinum toxin is a useful treatment in excessive drooling in saliva / J Neurol Neurosurg Psychiatry 67 : 697 ~
Bushara KO / 1997 / Sialorrhea in amyotrophic lateral sclerosis: a hypothesis of a new treatment botulinum toxin A injections of the parotid glands / Med Hypotheses 48 : 337
Coskun BU / 2007 / Histopathological and radiological investigations of the influence of botulinum toxin on the submandibular gland of the rat / Eur Arch Otorhinolaryngol 264
Banerjee KJ / 2006 / Parotid and submandibular botulinum toxin A injections for sialorrhoea in children with cerebral palsy / Dev Med Child Neurol 48 : 883 ~ 887
Bhatia KP / 1999 / Botulinum toxin is a useful treatment in excessive drooling in saliva / J Neurol Neurosurg Psychiatry 67 : 697 ~
Bushara KO / 1997 / Sialorrhea in amyotrophic lateral sclerosis: a hypothesis of a new treatment botulinum toxin A injections of the parotid glands / Med Hypotheses 48 : 337
Coskun BU / 2007 / Histopathological and radiological investigations of the influence of botulinum toxin on the submandibular gland of the rat / Eur Arch Otorhinolaryngol 264
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