지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 433 - 446 (14page)
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초록· 키워드
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Objective To investigate associations between angiotensin-converting enzyme (ACE) polymorphisms and muscle fatigability in 65-year-old Koreans. Method The study participants were 49 Koreans aged 65 years. ACE insertion/deletion (I/D) polymorphisms were determined by polymerase chain reaction and serum ACE activity, by spectrophotometry. Body mass index (BMI), body fat mass (BFM), and lean body mass (LBM) were determined. To evaluate muscle fatigability, dynamic Electromyography was used to measure maximum voluntary isometric contractions (MVICs) of ankle plantar flexor muscles. Patients were seated with their hips flexed at 90°, knees fully extended, and ankles at 0°. Continuous submaximal VICs (40% MVIC) were then performed, and contraction duration and EMG frequency changes during the initial 2 min were measured. A self-reported physical activity questionnaire was used to evaluate effects of ACE activity levels on muscle fatigability.Results Among the 49 volunteers, 15 showed II genotype; 22, ID genotype; and 12, DD genotype. Serum ACE activity levels were significantly higher in DD genotype subjects than in II genotype subjects (p<0.05). Furthermore, the duration of submaximal isometric contractions was longer in II and ID genotype subjects than in DD genotype subjects (p<0.05). Dynamic EMG showed significantly lower mean frequency changes in II genotype subjects than in DD genotype subjects (p<0.05). However, LBM, BFM, and BMI were independent of ACE genotypes.Conclusion ACE II genotype subjects showed significantly higher resistant to muscle fatigue than that by DD genotype subjects. However, body composition and BMI showed no correlations with ACE I/D polymorphisms.
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참고문헌 (26)
참고문헌 신청
Ali A / 2011 / Analysis of insertion/deletion polymorphisms of the angiotensin converting enzyme gene in Malaysian end-stage renal disease patients / J Renin Angiotensin Ald
Alvarez R / 2000 / Genetic variation in the renin-angiotensin system and athletic performance / Eur J Appl Physiol 82 : 117 ~ 120
Basmajian JV / 1985 / Muscles alive-their functions revealed by electromyography, 5th ed / Williams & Wilkins : 201 ~ 220
Dietze GJ / 2008 / Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasis / J Renin Angiotensin Aldosterone Syst 9 : 75
Frederiksen H / 2003 / Angiotensin I-converting enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival--a follow-up study of elderly Dani
Alvarez R / 2000 / Genetic variation in the renin-angiotensin system and athletic performance / Eur J Appl Physiol 82 : 117 ~ 120
Basmajian JV / 1985 / Muscles alive-their functions revealed by electromyography, 5th ed / Williams & Wilkins : 201 ~ 220
Dietze GJ / 2008 / Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasis / J Renin Angiotensin Aldosterone Syst 9 : 75
Frederiksen H / 2003 / Angiotensin I-converting enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival--a follow-up study of elderly Dani
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