지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 88 - 93 (6page)
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초록· 키워드
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Background: Hepcidin has recently been known as a negative regulatory hormone of iron. Hepcidin precursor, pro-hepcidin has been used as a surrogate and reported to be related to iron deficiency. We investigated serum pro-hepcidin levels in patients with iron deficiency anemia (IDA),anemia of chronic disorder (ACD) and ACD concomitant iron deficiency (ACD/ID) to assess its usefulness as a marker of iron deficiency and examined whether its level is associated with anemia, iron status or inflammation profiles involved in the synthesis of hepcidin.
Methods: We enrolled 50 patients with IDA, 46 with ACD, 12 with ACD/ID and 60 healthy controls. Complete blood cell count, iron parameters (iron, TIBC, trasferrin saturation, ferritin), C-reactive protein (CRP) and serum pro-hepcidin were measured.
Results: Patients with iron deficiency, the IDA group and ACD/ID group had lower serum pro-hepcidin levels than healthy controls and the ACD group. The cutoff value of pro-hepcidin for detecting iron deficiency was 230 ng/mL (sensitivity 88.1%, specificity 51.2%). Patients with increased CRP showed higher mean pro-hepcidin level than those with normal CRP and the difference was significant in the IDA group (P =0.02). And serum pro-hepcidin level was positively correlated with CRP level (r=0.30, P =0.04) in the IDA group but not with hemoglobin.
Conclusions: In patients with anemia, pro-hepcidin measurement may be useful for differentiating anemia patients with iron deficiency, IDA and ACD/ID from those with ACD. Serum pro-hepcidin levels may be more affected by inflammation than by the degree of anemia.
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참고문헌 (26)
참고문헌 신청
Cheng PP / 2011 / Hepcidin expression in anemia of chronic disease and concomitant iron-deficiency anemia / Clin Exp Med 11 : 33 ~ 42
Cook DJ / 1989 / Iron deficiency: definition and diagnosis / J Intern Med 226 : 349 ~ 355
Dallalio G / 2003 / Serum hepcidin in clinical specimens / Br J Haematol 122 : 996 ~ 1000
Fleming RE / 2001 / Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease / Proc Natl Acad Sci USA 98 : 8160 ~
Ganz T / 2008 / Immunoassay for human serum hepcidin / Blood 112 : 4292 ~ 4297
Cook DJ / 1989 / Iron deficiency: definition and diagnosis / J Intern Med 226 : 349 ~ 355
Dallalio G / 2003 / Serum hepcidin in clinical specimens / Br J Haematol 122 : 996 ~ 1000
Fleming RE / 2001 / Hepcidin: a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease / Proc Natl Acad Sci USA 98 : 8160 ~
Ganz T / 2008 / Immunoassay for human serum hepcidin / Blood 112 : 4292 ~ 4297
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