지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 181 - 186 (6page)
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Reports describing significant health risks due to inadequate vitamin D status continue to generate considerable interest amongst the medical and lay communities alike. Recent research on the various molecular activities of the vitamin D system, including the nuclear vitamin D receptor and other receptors for 1,25-dihydroxyvitamin D and vitamin D metab- olism, provides evidence that the vitamin D system carries out biological activities across a wide range of tissues similar to other nuclear receptor hormones. This knowledge provides physiological plausibility of the various health benefits claimed to be provided by vitamin D and supports the proposals for conducting clinical trials. The vitamin D system plays criti- cal roles in the maintenance of plasma calcium and phosphate and bone mineral homeo- stasis. Recent evidence confirms that plasma calcium homeostasis is the critical factor modulating vitamin D activity. Vitamin D activities in the skeleton include stimulation or in- hibition of bone resorption and inhibition or stimulation of bone formation. The three major bone cell types, which are osteoblasts, osteocytes and osteoclasts, can all respond to vita- min D via the classical nuclear vitamin D receptor and metabolize 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D to activate the vitamin D receptor and modulate gene expression.
Dietary calcium intake interacts with vitamin D metabolism at both the renal and bone tis- sue levels to direct either a catabolic action on the bone through the endocrine system when calcium intake is inadequate or an anabolic action through a bone autocrine or paracrine system when calcium intake is sufficient.
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참고문헌 (24)
참고문헌 신청
/ / National Health and Medical Research Council (NHMRC), NHMRC additional Levels of Evidence and Grades for Recommendations for Developers of guidelines
Anderson PH / 2005 / Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)2D3 levels / Bone 36 : 654 ~ 662
Anderson PH / 2008 / Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model / J Bone Miner Res 23 : 1789 ~ 1797
Anderson PH / 2011 / Morris HA. Vitamin D metabolism within bone cells: effects on bone structure and strength / Mol Cell Endocrinol 347 : 42 ~ 47
Anderson PH / 2012 / Vitamin D actions to regulate calcium and skeletal homeostasis / Clin Biochem 45 : 880 ~ 886
Anderson PH / 2005 / Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)2D3 levels / Bone 36 : 654 ~ 662
Anderson PH / 2008 / Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model / J Bone Miner Res 23 : 1789 ~ 1797
Anderson PH / 2011 / Morris HA. Vitamin D metabolism within bone cells: effects on bone structure and strength / Mol Cell Endocrinol 347 : 42 ~ 47
Anderson PH / 2012 / Vitamin D actions to regulate calcium and skeletal homeostasis / Clin Biochem 45 : 880 ~ 886
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