지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 263 - 270 (8page)
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초록· 키워드
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Objective To investigate risk factors for diabetic peripheral polyneuropathy and their correlation with the quantified severity of nerve dysfunction in patients with diabetes mellitus (DM).Methods A total of 187 diabetic patients with clinically suspected polyneuropathy (PN) were subclassified into 2 groups according to electrodiagnostic testing: a DM-PN group of 153 diabetic patients without electrophysiological abnormality and a DM+PN group of 34 diabetic patients with polyneuropathy. For all patients, age, sex, height, weight, duration of DM, and plasma glycosylated hemoglobin (HbA1c) level were comparatively investigated. A composite score was introduced to quantitatively analyze the results of the nerve conduction studies. Logistic regression analysis and multiple regression analysis were used to evaluate correlations between significant risk factors and severity of diabetic polyneuropathy.Results The DM+PN group showed a significantly higher HbA1c level and composite score, as compared with the DM-PN group. Increased HbA1c level and old age were significant predictive factors for polyneuropathy in diabetic patients (odds ratio=5.233 and 4.745, respectively). In the multiple linear regression model, HbA1c and age showed a significant positive association with composite score, in order (β=1.560 and 0.253, respectively). Conclusion Increased HbA1c level indicative of a state of chronic hyperglycemia was a risk factor for polyneuropathy in diabetic patients and a quantitative measure of its severity.
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참고문헌 (25)
참고문헌 신청
Gallagher EJ / 2011 / The metabolic syndrome: from insulin resistance to obesity and diabetes / Med Clin North Am 95:855~873
Gionfriddo MR / 2014 / The 2013 American Association of Clinical Endocrinologists’ diabetes mellitus management recommendations: improvements needed / JAMA Intern Med 174:179~180
International Expert Committee / 2009 / International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes / Diabetes Care 32:1327~1334
Deli G / 2013 / Diabetic neuropathies: diagnosis and management / Neuroendocrinology 98:267~280
Feng Y / 2011 / The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus / J Vasc Surg 53:220-226.e1~220-226.e5
Gionfriddo MR / 2014 / The 2013 American Association of Clinical Endocrinologists’ diabetes mellitus management recommendations: improvements needed / JAMA Intern Med 174:179~180
International Expert Committee / 2009 / International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes / Diabetes Care 32:1327~1334
Deli G / 2013 / Diabetic neuropathies: diagnosis and management / Neuroendocrinology 98:267~280
Feng Y / 2011 / The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus / J Vasc Surg 53:220-226.e1~220-226.e5
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