지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 44 - 54 (11page)
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초록· 키워드
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배경: 동반생물학적표지자(Companion biomarker)는 특정 치료제와의 조합으로 이용되어 반응성 또는 심한 독성 가능성을 미리 예측할 수 있도록 도와주는 것이다. 이 논문에서는 암 환자에서 치료의 방향을 제시하는 데 있어서의 동반생물학적표지자의 역할이 검토될 것이다.
내용: 유방암에서의 에스트로젠 수용체나 HER 2 (human epidermal growth factor receptor 2)와 같은 이미 확립된 동반생물학적표지자들 뿐 아니라, 최근 수년간 새로운 몇몇 동반생물학적표지자들이 등장하였다. 이들은 항-상피세포 성장인자 수용체 항체(anti-epidermal growth factor receptor antibodies; cetuximab 또는 panitumumab) 치료효과를 보일 것으로 예상되는 진행성 대장암환자들을 선택하기 위한 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) 돌연변이, 진행성 비소세포성폐암(non–small cell lung cancer, 비소세포성폐암) 환자들 중 타이로신활성효소 억제제(tyrosine kinase inhibitors; gefitinib 또는 erlotinib) 치료 적용대상을 선택하기 위한 epidermal growth factor receptor (EGFR) 돌연변이, 항BRAF 제제(vemurafenib and dabrafenib) 치료 대상이 될 수 있는 진행성 흑색종 환자의 선별을 위한 v-raf murine sarcoma viral oncogene homolog B1 (BRAF) 돌연변이, 그리고 crizotinib에 치료효과가 있을 것으로 보이는 비소세포성폐암 환자들을 찾아내기 위한 anaplastic lymphoma receptor tyrosine kinase (ALK) 전위 등이다.
요약: 동반생물학적표지자의 활용은 약제의 효과 향상, 독성 감소를 가져올 것이며, 암 치료에 대한 보다 개인별 최적화된 접근을 가능하게 할 것이다.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Abramson V / 2011 / New strategies in HER2-overexpressing breast cancer : many combinations of targeted drugs available / Clin Cancer Res 17 : 952 ~ 958
Aebi S / 2011 / Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up / Ann Oncol 22 (Suppl 6) : vi12 ~ vi24
Burstein HJ / 2010 / American Society of Clinical Oncology clinical practice guideline : update on adjuvant endocrine therapy for women with hormone receptor-positive breast
Chia SK / 2011 / With maturity comes confidence : EBCTCG tamoxifen update / Lancet 378 : 747 ~ 749
Early Breast Cancer Trialists’ Collaborative Group / 2011 / Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-lev
Aebi S / 2011 / Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up / Ann Oncol 22 (Suppl 6) : vi12 ~ vi24
Burstein HJ / 2010 / American Society of Clinical Oncology clinical practice guideline : update on adjuvant endocrine therapy for women with hormone receptor-positive breast
Chia SK / 2011 / With maturity comes confidence : EBCTCG tamoxifen update / Lancet 378 : 747 ~ 749
Early Breast Cancer Trialists’ Collaborative Group / 2011 / Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-lev
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