지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 232 - 236 (5page)
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초록· 키워드
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Atypical chronic myeloid leukemia (aCML) is a rare leukemic disorder that shows myelodysplastic and myeloproliferative features simultaneously.
The Janus kinase 2 gene V617F mutation (JAK2V617F) in aCML has been the source of much controversy. Some JAK2V617F positive cases have been reported but others observed no JAK2V617F mutation in aCML as defined by WHO classification. Recently, we experienced a case of aCML with JAK2V617F mutation with typical myelodysplastic/myeloproliferative features in peripheral blood and bone marrow aspirates. The karyotype was normal and no BCR/ABL1, PDGFRA or PDGFRB gene rearrangement was noted with FISH analysis. JAK2V617F mutation of the case was identified with amplification refractory mutation system PCR and direct sequencing. We also studied JAK2V617F mutation status in 3 additional cases of previously diagnosed aCML in our institution, but no mutation was identified.Atypical chronic myeloid leukemia (aCML) is a rare leukemic disorder that shows myelodysplastic and myeloproliferative features simultaneously. The Janus kinase 2 gene V617F mutation (JAK2V617F) in aCML has been the source of much controversy. Some JAK2V617F positive cases have been reported but others observed no JAK2V617F mutation in aCML as defined by WHO classification. Recently, we experienced a case of aCML with JAK2V617F mutation with typical myelodysplastic/myeloproliferative features in peripheral blood and bone marrow aspirates. The karyotype was normal and no BCR/ABL1, PDGFRA or PDGFRB gene rearrangement was noted with FISH analysis. JAK2V617F mutation of the case was identified with amplification refractory mutation system PCR and direct sequencing. We also studied JAK2V617F mutation status in 3 additional cases of previously diagnosed aCML in our institution, but no mutation was identified.
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참고문헌 (14)
참고문헌 신청
Bennett JM / 1994 / The chronic myeloid leukaemias: guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia / Br J
Boyle EB / 1998 / Accuracy of DNA amplification from archival hematological slides for use in genetic biomarker studies / Cancer Epidemiol Biomarkers Prev 7 : 1127 ~ 1131
Campiotti L / 2009 / JAK2 mutation and atypical chronic myeloid leukemia / Leuk Res 33 : 166 ~ 167
Ernst T / 2010 / Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms / Haematologica 95 : 1473 ~ 1480
Fend F / 2008 / Atypical chronic myeloid leukemia as defined in the WHO classification is a JAK2 V617F negative neoplasm / Leuk Res 32 : 1931 ~ 1935
Boyle EB / 1998 / Accuracy of DNA amplification from archival hematological slides for use in genetic biomarker studies / Cancer Epidemiol Biomarkers Prev 7 : 1127 ~ 1131
Campiotti L / 2009 / JAK2 mutation and atypical chronic myeloid leukemia / Leuk Res 33 : 166 ~ 167
Ernst T / 2010 / Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms / Haematologica 95 : 1473 ~ 1480
Fend F / 2008 / Atypical chronic myeloid leukemia as defined in the WHO classification is a JAK2 V617F negative neoplasm / Leuk Res 32 : 1931 ~ 1935
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