지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 122 - 126 (5page)
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초록· 키워드
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Propionibacterium acnes is a gram-positive anaerobic bacillus and a normal inhabitant of the skin. Although it is often considered a contaminant of blood cultures, it can occasionally cause serious infections, including postoperative central nervous system infections. Here, we report the case of a 70-yr-old man who developed a large cerebral abscess caused by P. acnes 13 months after neurosurgery. Immediate gram staining of the pus from his brain revealed the presence of gram-positive coccobacilli. However, colony growth was observed only after 5 days of culture. Therefore, we performed 16S rRNA gene sequencing of the pus specimen. The isolate was identified as P. acnes. The colonies developed 9 days after the initial culture. The API Rapid ID 32A test (bioMérieux, France) was performed using a colony, but an unacceptable profile was obtained. Then, the pus was transferred into the enrichment broths of the BACTEC FX (Becton Dickinson, USA) and BacT/Alert 3D (bioMérieux, Organon Teknika, USA) systems, but only the BACTEC FX system could detect growth after 5 days. We performed 16S rRNA gene sequencing and API Rapid 32A profiling with a colony recovered from Brucella agar, which was inoculated with the microbial growth in the enrichment broth from the BACTEC FX system. The organism was identified as P. acnes by both methods. This case suggests that 16S rRNA gene sequencing may be a useful alternative for identifying slowly growing P. acnes from specimens that do not show growth after 5 days of culture.
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참고문헌 (18)
참고문헌 신청
Barazi SA / 2003 / Delayed postoperative intracerebral abscess caused by Proprionibacterium acnes: case report and review of the literature / Br J Neurosurg 17 : 336 ~ 339
Breitkopf C / 2005 / Impact of a molecular approach to improve the microbiological diagnosis of infective heart valve endocarditis / Circulation 111 : 1415 ~ 1421
Brook I / 1991 / Infections caused by Propionibacterium species / Rev Infect Dis 13 : 819 ~ 822
Clinical and Laboratory Standards Institute / 2008 / Interpretive criteria for identification of bacteria and fungi by DNA target sequencing: approved guideline. MM18-A / Clinical and La
Conen A / 2008 / Characteristics and treatment outcome of cerebrospinal fluid shunt-associated infections in adults: a retrospective analysis over an 11-year period / Clin In
Breitkopf C / 2005 / Impact of a molecular approach to improve the microbiological diagnosis of infective heart valve endocarditis / Circulation 111 : 1415 ~ 1421
Brook I / 1991 / Infections caused by Propionibacterium species / Rev Infect Dis 13 : 819 ~ 822
Clinical and Laboratory Standards Institute / 2008 / Interpretive criteria for identification of bacteria and fungi by DNA target sequencing: approved guideline. MM18-A / Clinical and La
Conen A / 2008 / Characteristics and treatment outcome of cerebrospinal fluid shunt-associated infections in adults: a retrospective analysis over an 11-year period / Clin In
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