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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 61 - 71 (11page)
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Better biomarkers are urgently needed to cancer detection, diagnosis, and prognosis. While the genomics community is making significant advances in understanding the molecular basis of disease, proteomics will delineate the functional units of a cell, proteins and their intricate interaction network and signaling pathways for the underlying disease. Great progress has been made to characterize thousands of proteins qualitatively and quantitatively in complex biological systems by utilizing multi-dimensional sample fractionation strategies, mass spectrometry and protein microarrays. Comparative/quantitative analysis of high-quality clinical biospecimen (e.g., tissue and biofluids) of human cancer proteome landscape has the potential to reveal protein/peptide biomarkers responsible for this disease by means of their altered levels of expression, post-translational modifications as well as different forms of protein variants. Despite technological advances in proteomics, major hurdles still exist in every step of the biomarker development pipeline. The National Cancer Institute’s Clinical Proteomic Technologies for Cancer initiative (NCI-CPTC) has taken a critical step to close the gap between biomarker discovery and qualification by introducing a pre-clinical “verification” stage in the pipeline, partnering with clinical laboratory organizations to develop and implement common standards, and developing regulatory science documents with the US Food and Drug Administration to educate the proteomics community on analytical evaluation requirements for multiplex assays in order to ensure the safety and effectiveness of these tests for their intended use.
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참고문헌 (71)
참고문헌 신청
An HJ / 2010 / A glycomics approach to the discovery of potential cancer biomarkers / Methods Mol Biol 600:199~213
Choudhary C / 2010 / Decoding signalling networks by mass spectrometry-based proteomics / Nat Rev Mol Cell Biol 11:427~439
Madian AG / 2010 / Profiling carbonylated proteins in human plasma / J Proteome Res 9:1330~1343
Iwabata H / 2005 / Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies / Proteomics 5:4653~4664
Ceroni A / 2010 / Systematic analysis of the IgG antibody immune response against varicella zoster virus (VZV) using a self-assembled protein microarray / Mol Biosyst 6:1604~1610
Choudhary C / 2010 / Decoding signalling networks by mass spectrometry-based proteomics / Nat Rev Mol Cell Biol 11:427~439
Madian AG / 2010 / Profiling carbonylated proteins in human plasma / J Proteome Res 9:1330~1343
Iwabata H / 2005 / Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies / Proteomics 5:4653~4664
Ceroni A / 2010 / Systematic analysis of the IgG antibody immune response against varicella zoster virus (VZV) using a self-assembled protein microarray / Mol Biosyst 6:1604~1610
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