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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 339 - 344 (6page)
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In patients with hemolytic anemia associated with spherocytosis, differential diagnosis has to be made whether the hemolysis is immune-mediated or of non-immune origin. We report a case of hereditary spherocytosis in a 12-yr-old male child, in whom flow-assisted diagnosis was made. In this case, diagnosis was not determined because routine laboratory workups for hereditary spherocytosis yielded discrepant results: positive osmotic fragility test, positive direct antiglobulin test, and normal result in the red cell membrane protein sodium dodecyl succinimide polyacrylamide gel electrophoresis. However, all flow cytometry-based tests, such as osmotic fragility, direct antiglobulin, and eosin 5-maleimide binding test, yielded results compatible with hereditary spherocytosis. Additionally, in family study, the results of eosin 5-maleimide binding test suggested his disease being hereditary. In cases with diagnostic difficulties, flow cytometry may be used as an alternative tool, which can provide additional information in the differential diagnosis of hemolytic anemia with spherocytosis. (Korean J Lab Med 2010;30:339-44)
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등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Bolton-Maggs PH / 2004 / General Haematology Task Force of the British Committee for Standards in Haematology. Guidelines for the diagnosis and management of hereditary spher
Boyd AS / 1989 / Hereditary spherocytosis / Am Fam Physician 39 (1) : 67 ~ 172
Downes KA / 2008 / Pretransfusion testing in Technical manual. 16th ed / American Association of Blood Banks : 437 ~ 463
Gallagher PG / 1998 / Disorders of the erythrocyte membrane. In: Nathan DG and Orkin SH, eds. Nathan and Oski’s hematology of infancy and childhood. 5th ed / WB Saunders : 544 ~ 664
Garratty G / 1987 / The significance of IgG on the red cell surface / Transfus Med Rev 1 : 47 ~ 57
Boyd AS / 1989 / Hereditary spherocytosis / Am Fam Physician 39 (1) : 67 ~ 172
Downes KA / 2008 / Pretransfusion testing in Technical manual. 16th ed / American Association of Blood Banks : 437 ~ 463
Gallagher PG / 1998 / Disorders of the erythrocyte membrane. In: Nathan DG and Orkin SH, eds. Nathan and Oski’s hematology of infancy and childhood. 5th ed / WB Saunders : 544 ~ 664
Garratty G / 1987 / The significance of IgG on the red cell surface / Transfus Med Rev 1 : 47 ~ 57
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