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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 388 - 393 (6page)
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Background : Since April 2009, novel influenza A (H1N1) infection is spreading throughout theworld. This infection might be fatal for immunocompromised patients who are at a potentially high risk of developing infectious complications. We investigated the detection rate and features of H1N1 infection in immunocompromised patients.
Methods : Between August 2009 and February 2010, we examined 8,112 subjects, including 390 immunocompromised patients, for H1N1. Swab samples were taken from the nose and throat of the participants. Real-time PCR was performed to identify H1N1 viral genes.
Results : Positive results were obtained in 2,953/8,112 (36.4%) subjects and 46/390 (11.8%) immunocompromised patients. H1N1 was identified in 8.7% patients with solid cancer, 12.9% patients with hematologic malignancy, 16.7% patients with chronic renal disease, and 14.5% patients with kidney transplantation. The mean cycle threshold (Ct) value of PCR was significantly lower (P<0.05) in patients with hematologic malignancy as compared to that in patients with chronic renal disease and control subjects. Four patients died due to respiratory complications.
Conclusions : The detection rate of H1N1 was significantly lower in immunocompromised patients than in other patients. The Ct value of patients with hematologic malignancy was significantly lower than that of other immunocompromised patients and control subjects. (Korean J Lab Med 2010;30:388-93)
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참고문헌 (20)
참고문헌 신청
Centers for Disease Control and Prevention / 2009 / Outbreak of swine-origin influenza A (H1N1) virus infection - Mexico, March-April 2009 / MMWR Morb Mortal Wkly Rep 58 : 46
Centers for Disease Control and Prevention / 2009 / Surveillance for pediatric deaths associated with 2009 pandemic influenza A (H1N1) virus infection - United States, April-
Chan M / / World now at the start of 2009 influenza pandemic
Chemaly RF / 2006 / Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major can
Clements ML / 1986 / Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus / J Clin Microbiol 24 : 157 ~ 160
Centers for Disease Control and Prevention / 2009 / Surveillance for pediatric deaths associated with 2009 pandemic influenza A (H1N1) virus infection - United States, April-
Chan M / / World now at the start of 2009 influenza pandemic
Chemaly RF / 2006 / Respiratory viral infections in adults with hematologic malignancies and human stem cell transplantation recipients: a retrospective study at a major can
Clements ML / 1986 / Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus / J Clin Microbiol 24 : 157 ~ 160
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