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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 361 - 365 (5page)
이용수
초록· 키워드
오류제보하기
Extremely weak D variants called DEL are serologically detectable only by adsorption-elution techniques. A nucleotide change of exon 9 in RHD gene, RHD (K409K, 1227G>A) allelic variant is present in almost all the DEL individuals of East Asians. No DEL phenotype has yet been shown to
induce a primary alloanti-D immunization in East Asia. A 68-yr-old D-negative Korean man was negative for anti-D at admission, and he developed alloanti-D after transfusion of red blood cells (RBC) from 4 apparently D-negative donors. Four donors who typed D-negative by routine serologic test
were analyzed by real-time PCR for RHD gene and RHD (K409K). One donor was found to have RHD (K409K). This is the first case in which DEL RBCs with RHD (K409K) induced a primary alloanti- D immunization in Asian population. Because the DEL phenotype can induce an anti-D immunization
in D-negative recipients, further discussion is needed whether RhD negative donors should be screened by molecular method and what an efficient genotyping method is for detecting the RHD gene carriers in Korea.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Aubin JT / 1997 / Specificity and sensitivity of RHD genotyping methods by PCRbased DNA amplification / Br J Haematol 98 : 356 ~ 364
Avent ND / 1997 / Evidence of genetic diversity underlying Rh D-, weak D (Du), and partial D phenotypes as determined by multiplex polymerase chain reaction analysis of the
Avent ND / 2000 / The Rh blood group system: a review / Blood 95 : 375 ~ 387
Daniels G / 1995 / Human blood groups. 1st ed / Blackwell Science
Flegel WA / 2009 / Six years' experience performing RHD genotyping to confirm D- red blood cell units in Germany for preventing anti-D immunizations / Transfusion 49 : 465 ~
Avent ND / 1997 / Evidence of genetic diversity underlying Rh D-, weak D (Du), and partial D phenotypes as determined by multiplex polymerase chain reaction analysis of the
Avent ND / 2000 / The Rh blood group system: a review / Blood 95 : 375 ~ 387
Daniels G / 1995 / Human blood groups. 1st ed / Blackwell Science
Flegel WA / 2009 / Six years' experience performing RHD genotyping to confirm D- red blood cell units in Germany for preventing anti-D immunizations / Transfusion 49 : 465 ~
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