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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 279 - 281 (3page)
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초록· 키워드
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The aminoglycoside 6´-N-acetyltransferases of type Ib (aac(6´)-Ib) gene confers resistance to amikacin, tobramycin, kanamycin, and netilmicin but not gentamicin. However, some isolates harboring this gene show reduced susceptibility to amikacin. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) recommends a revision of the phenotypic description for isolates harboring the aac(6´)-Ib gene. In this study, we determined the aminoglycoside susceptibility profiles of 58 AAC(6´)-Ib-producing Enterobacter cloacae isolates. On the basis of the CLSI and EUCAST breakpoints, a large proportion (84.5% and 55.2%, respectively) of these 58 isolates were found to be susceptible to amikacin. However, among the isolates that were shown to be anikacin-susceptible according to the CLSI and EUCAST breakpoints, only 30.6% and 18.8% isolates, respectively, could be considered to have intermediate resistance on the basis of the EUCAST expert rules. Further studies should be conducted to determine the aminoglycoside susceptibility profiles of aac(6´)-Ib-harboring isolates from various geographic regions and to monitor the therapeutic efficacy of amikacin in infections caused by these isolates.
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참고문헌 (11)
참고문헌 신청
Casin I / 1998 / Aminoglycoside 6´-N-acetyltransferase variants of the Ib type with altered substrate profile in clinical isolates of Enterobacter cloacae and Citrobacter fr
Caulin E / 1996 / Resistance to amikacin and isepamicin in rabbits with experimental endocarditis of an aac(6´)-Ib-bearing strain of Klebsiella pneumoniae susceptible in vi
Clinical and Laboratory Standards Institute (CLSI) / 2009 / Performance standards for antimicrobial susceptibility testing; Nineteenth informational supplement, M100-S19 / Clinical and L
Kim JY / 2008 / Occurrence and mechanisms of amikacin resistance and its association with β-lactamases in Pseudomonas aeruginosa: a Korean nationwide study / J Antimicrob Ch
Kim SY / 2009 / Prevalence and characteristics of aac(6’)-Ib-cr in AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens: a multicenter study fr
Caulin E / 1996 / Resistance to amikacin and isepamicin in rabbits with experimental endocarditis of an aac(6´)-Ib-bearing strain of Klebsiella pneumoniae susceptible in vi
Clinical and Laboratory Standards Institute (CLSI) / 2009 / Performance standards for antimicrobial susceptibility testing; Nineteenth informational supplement, M100-S19 / Clinical and L
Kim JY / 2008 / Occurrence and mechanisms of amikacin resistance and its association with β-lactamases in Pseudomonas aeruginosa: a Korean nationwide study / J Antimicrob Ch
Kim SY / 2009 / Prevalence and characteristics of aac(6’)-Ib-cr in AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens: a multicenter study fr
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