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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 220 - 224 (5page)
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The most common recurrent cytogenetic abnormalities in T-lymphoblastic leukemia (T-acute lymphoblastic leukemia [T-ALL]) involve T-cell receptor (TCR) loci and a variety of partner genes, including HOX11, HOX11L2, MYC, and TAL1. In this report, we present a rare case involving simultaneous translocation of the TCR α/δ loci with different partner loci (Xq22 and 12p13); this resulted in a poor prognosis. Chromosomal analysis showed 46,Y,t(X;14)(q22;q11.2),t(12;14)(p13;q11.2) and FISH analysis by using a T-cell receptor alpha delta DNA probe, Split Signal (DakoCytomation, Denmark), showed translocations at the same TCR α/δ locus on both chromosomes. FISH with 2 bacterial artificial chromosome clones showed break apart signal, which suggests involvement of the IRS4 gene. To our knowledge, this is the first report of T-ALL in which both TCR α/δ loci were translocated with different partner loci, and 1 of the partner loci, Xq22, was a rare translocation partner locus that included IRS4 gene.
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참고문헌 (16)
참고문헌 신청
Borowitz M / 2008 / T lymphoblastic Leukeaemia/lymphoma, In WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed / IARC Press : 176 ~ 178
Chiaretti S / 2009 / T-cell acute lymphoblastic leukemia / Haematologica 94 : 160 ~ 162
Clappier E / 2006 / Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias / Leukemia 20 : 82 ~ 86
Douet-Guilbert N / 2004 / Cytogenetic studies in T-cell acute lymphoblastic leukemia (1981-2002) / Leuk Lymphoma 45 : 287 ~ 290
Fantin VR / 1999 / Insulin receptor substrate 4 supports insulin- and interleukin 4-stimulated proliferation of hematopoietic cells / Biochem Biophys Res Commun 260 : 718 ~
Chiaretti S / 2009 / T-cell acute lymphoblastic leukemia / Haematologica 94 : 160 ~ 162
Clappier E / 2006 / Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias / Leukemia 20 : 82 ~ 86
Douet-Guilbert N / 2004 / Cytogenetic studies in T-cell acute lymphoblastic leukemia (1981-2002) / Leuk Lymphoma 45 : 287 ~ 290
Fantin VR / 1999 / Insulin receptor substrate 4 supports insulin- and interleukin 4-stimulated proliferation of hematopoietic cells / Biochem Biophys Res Commun 260 : 718 ~
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