지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 119 - 125 (7page)
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초록· 키워드
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Background: D-dimer is a reliable and sensitive index of fibrin deposition and stabilization. As such, its presence in plasma should be indicative of thrombus formation. There are many conditions unrelated to thrombosis in which D-dimer concentrations are high, however, making its positive predictive value rather poor.
Content: Notwithstanding these limitations, D-dimer can be regarded as a most valuable laboratory tool to diagnose and manage a vast array of thrombosis related clinical conditions, including (a) diagnosis of venous thromboembolism (VTE), (b) identification of individuals at increased risk of first thrombotic event (both arterial and venous), (c) identification of individuals at increased risk of recurrent VTE, (d) establishment of the optimal duration of secondary prophylaxis after a first episode of VTE, (e) pregnancy monitoring, and (f) diagnosis/monitoring of disseminated intravascular coagulation (DIC). This article is aimed at reviewing the merits and pitfalls of these applications.
Summary: From my analysis of the literature, I draw the following conclusions. (a) D-dimer, as measured by a sensitive test, can be safely used to exclude VTE in symptomatic outpatients, provided that it is used in combination with the pretest clinical probability. (b) High concentrations of Ddimer are associated with an increased risk of recurrent VTE. (c) Patients who present with D-dimer above cutoff after stopping the regular course of oral anticoagulation benefit from extended prophylaxis. (d) Finally, D-dimer can be used as a fibrin-related degradation marker for the diagnosis/ management of patients with DIC.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bounameaux H / 1991 / Measurement of D-dimer in plasma as diagnostic aid in suspected pulmonary embolism / Lancet 337 : 196 ~ 200
Cogo A / 1998 / Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study / BMJ 316 : 17 ~ 20
Cushman M / 2003 / Fibrin fragment D-dimer and the risk of future venous thrombosis / Blood 101 : 1243 ~ 1248
Di Nisio M / 2007 / Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review / J Thromb Haemost 5 : 296 ~ 304
Elms MJ / 1986 / Rapid detection of cross-linked fibrin degradation products in plasma using monoclonal antibody-coated latex particles / Am J Clin Pathol 85 : 360 ~ 364
Cogo A / 1998 / Compression ultrasonography for diagnostic management of patients with clinically suspected deep vein thrombosis: prospective cohort study / BMJ 316 : 17 ~ 20
Cushman M / 2003 / Fibrin fragment D-dimer and the risk of future venous thrombosis / Blood 101 : 1243 ~ 1248
Di Nisio M / 2007 / Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review / J Thromb Haemost 5 : 296 ~ 304
Elms MJ / 1986 / Rapid detection of cross-linked fibrin degradation products in plasma using monoclonal antibody-coated latex particles / Am J Clin Pathol 85 : 360 ~ 364
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