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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 395 - 401 (7page)
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초록· 키워드
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Mitochondria are the powerhouses of the cell as well as the primary site of hematopoiesis, which also occurs in the cytoplasm. Hematopoietic stem cells (HSCs) are characterized by a very high turnover rate, and are thus considered to be relatively free from the age-related insults generated by mitochondria. However, HSCs are also subject to these age-related insults, including the incidence of myeloid proliferative diseases, marrow failure, hematopoietic neoplasms, and deterioration of the adaptive human immune system. Recently, NAD+ dietary supplements, known as niacin or vitamin B3, including tryptophan, nicotinic acid, nicotinamide, and the newly identified NAD+ precursor nicotinamide riboside, have been shown to play a role in restoring adult stem cell function through the amelioration of mitochondrial dysfunction. This insight motivated a study that focused on reversing aging-related cellular dysfunction in adult mouse muscle stem cells by supplementing their diet with nicotinamide riboside. The remedial effect of nicotinamide riboside enhanced mitochondrial function in these muscle stem cells in a SIRT1-dependent manner, affecting cellular respiration, membrane potential, and production of ATP. Accordingly, numerous studies have demonstrated that sirtuins, under nuclear/mitochondrial control, have age-specific effects in determining HSC phenotypes. Based on the evidence accumulated thus far, we propose a clinical intervention for the restoration of aged HSC function by improving mitochondrial function through NAD+ precursor supplementation.
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참고문헌 (37)
참고문헌 신청
Kujoth G / 2005 / Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging / Science 309:481~484
Trifunovic A / 2004 / Premature ageing in mice expressing defective mitochondrial DNA polymerase / Nature 429:417~423
Bratic A / 2013 / The role of mitochondria in aging / J Clin Invest 123:951~957
Brown K / 2013 / SIRT3 reverses aging-associated degeneration / Cell Rep 3:319~327
Wang H / 2016 / SIRT6 controls hematopoietic stem cell homeostasis through epigenetic regulation of Wnt signaling / Cell Stem Cell 18:495~507
Trifunovic A / 2004 / Premature ageing in mice expressing defective mitochondrial DNA polymerase / Nature 429:417~423
Bratic A / 2013 / The role of mitochondria in aging / J Clin Invest 123:951~957
Brown K / 2013 / SIRT3 reverses aging-associated degeneration / Cell Rep 3:319~327
Wang H / 2016 / SIRT6 controls hematopoietic stem cell homeostasis through epigenetic regulation of Wnt signaling / Cell Stem Cell 18:495~507
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