지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 34 - 38 (5page)
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초록· 키워드
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Background: D-dimer is used widely as a diagnostic aid in low- and moderate-risk patients with suspected venous thromboembolism (VTE). While our laboratory utilizes VIDAS D-dimer analyzer (bioMérieux SA, France), our emergency department (ED) recently procured a D-dimer analyzer AQT90 FLEX (Radiometer Medical ApS, Denmark) for point of care testing (POCT) to facilitate patient management. We aimed to determine whether the time taken to receive D-dimer results using the 2 different analyzers differed significantly and to quantify the limits of agreement between the results of the 2 methods measured on the same patient. Methods: Adult patients presenting to the ED and requiring diagnostic workup for suspected VTE were included in this prospective observational study. Patients underwent simultaneous D-dimer measurements using the 2 different analyzers. Results: The paired results from 104 patients were analyzed. The median time for the Ddimer results from triage by VIDAS was 258 min (Inter-quartile range [IQR], 173-360) and by POCT was 146 min (IQR, 55-280.5); the median time difference was 101.5 min (IQR, 82-125.5). On an average, POCT D-dimer values were 15% lower on the same sample (limits of agreement, 34-213%). POCT predicted 83% of VIDAS positive results (sensitivity, 83.3%[95% confidence interval (CI), 70.4-91.3%]; specificity, 100% [95% CI, 93.6-100%]). All patients with positive imaging were identified correctly by both methods. Conclusions: POCT delivers D-dimer results in significantly shorter turnaround times than pathology services; however, poor bioequivalence between VIDAS and POCT raises the issue of acceptability for use in the ED.
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참고문헌 (13)
참고문헌 신청
Bland JM / 1986 / Statistical methods for assessing agreement between two methods of clinical measurement / Lancet 1 : 307 ~ 310
Brotman DJ / 2003 / Limitations of Ddimer testing in unselected inpatients with suspected venous thromboembolism / Am J Med 114 : 276 ~ 282
Dempfle CE / 2005 / Validation, calibration, and specificity of quantitative D-dimer assays / Semin Vasc Med 5 : 315 ~ 320
Di Nisio M / 2007 / Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review / J Thromb Haemost 5 : 296 ~ 304
Geersing GJ / 2009 / Excluding venous thromboembolism using point of care D-dimer tests in outpatients: a diagnostic meta-analysis / BMJ 339 : b2990 ~
Brotman DJ / 2003 / Limitations of Ddimer testing in unselected inpatients with suspected venous thromboembolism / Am J Med 114 : 276 ~ 282
Dempfle CE / 2005 / Validation, calibration, and specificity of quantitative D-dimer assays / Semin Vasc Med 5 : 315 ~ 320
Di Nisio M / 2007 / Diagnostic accuracy of D-dimer test for exclusion of venous thromboembolism: a systematic review / J Thromb Haemost 5 : 296 ~ 304
Geersing GJ / 2009 / Excluding venous thromboembolism using point of care D-dimer tests in outpatients: a diagnostic meta-analysis / BMJ 339 : b2990 ~
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