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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 475 - 477 (3page)
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Although rearrangements involving each ETV6 and ABL1 gene are some of the most commonly observed chromosomal translo- cations in hematological malignancies [1, 2], an ETV6/ABL1 re- arrangement is very rare, and only 29 such cases have been re- ported to date [3]. This fusion has been associated with a wide range of hematological malignancies, including 11 cases of atyp- ical chronic myeloid leukemia ( BCR/ABL1 negative), 3 cases of myeloproliferative neoplasm (MPN), 5 cases of acute myeloid leukemia, and 10 cases of ALL. The rarity of this rearrangement is related to the inverse transcriptional orientation of the 2 genes relative to the centromeres, because it would involve at least 2 events to form an in-frame fusion transcript [3]. Here, we report a case of B-ALL with ETV6/ABL1 rearrangement.
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참고문헌 (4)
참고문헌 신청
De Braekeleer E / 2011 / ABL1 fusion genes in hematological malignancies: a review / Eur J Haematol 86 : 361 ~ 371
De Braekeleer E / 2012 / ETV6 fusion genes in hematological malignancies: a review / Leuk Res 36 : 945 ~ 961
Gancheva K / 2013 / Myeloproliferative neoplasm with ETV6-ABL1 fusion: a case report and literature review / Mol Cytogenet 6 : 39 ~
Park J / 2013 / Variant of ETV6/ABL1 gene is associated with leukemia phenotype / Acta Haematol 129 : 78 ~ 82
De Braekeleer E / 2012 / ETV6 fusion genes in hematological malignancies: a review / Leuk Res 36 : 945 ~ 961
Gancheva K / 2013 / Myeloproliferative neoplasm with ETV6-ABL1 fusion: a case report and literature review / Mol Cytogenet 6 : 39 ~
Park J / 2013 / Variant of ETV6/ABL1 gene is associated with leukemia phenotype / Acta Haematol 129 : 78 ~ 82
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