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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 304 - 306 (3page)
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Anaphylactic transfusion reactions are rare complications of blood transfusions. Anhaptoglobinemia, a condition that has high incidence in Asia, can cause allergic transfusion reactions or anaphylaxis in severe cases. A 50-yr-old Korean woman was diagnosed with relapsed acute promyelocytic leukemia. She developed thrombocytopenia during chemotherapy and an anaphylactic transfusion reaction on the 4th and 5th platelet transfusions immediately after the transfusion of the platelet concentrates was initiated. Blood analysis showed no detectable serum haptoglobin. We examined her genetic phenotype and detected anhaptoglobinemia, which occurs because of an allelic deletion in the Hp gene cluster. The presence of an antibody against haptoglobin was detected by performing ELISA. To prevent anaphylactic reactions, apheresis platelets were transfused after washing. Consequently, anaphylactic transfusion reactions did not develop. Here, we report the first case of anhaptoglobinemia causing anaphylactic transfusion reaction in Korea.
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참고문헌 (11)
참고문헌 신청
Heddle NM / 1994 / The role of the plasma from platelet concentrates in transfusion reactions / N Engl J Med 331 : 625 ~ 628
Jilma-Stohlawetz P / 2012 / The effect of plasma removal from apheresis platelet concentrates on platelet function / Vox Sang 102 : 258 ~ 260
Koda Y / 1998 / The haptoglobin-gene deletion responsible for anhaptoglobinemia / Am J Hum Genet 62 : 245 ~ 252
Koda Y / 2000 / Simple PCR detection of haptoglobin gene deletion in anhaptoglobinemic patients with antihaptoglobin antibody that causes anaphylactic transfusion reactions /
Levy AP / 2010 / Haptoglobin: basic and clinical aspects / Antioxid Redox Signal 12 : 293 ~ 304
Jilma-Stohlawetz P / 2012 / The effect of plasma removal from apheresis platelet concentrates on platelet function / Vox Sang 102 : 258 ~ 260
Koda Y / 1998 / The haptoglobin-gene deletion responsible for anhaptoglobinemia / Am J Hum Genet 62 : 245 ~ 252
Koda Y / 2000 / Simple PCR detection of haptoglobin gene deletion in anhaptoglobinemic patients with antihaptoglobin antibody that causes anaphylactic transfusion reactions /
Levy AP / 2010 / Haptoglobin: basic and clinical aspects / Antioxid Redox Signal 12 : 293 ~ 304
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