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Micro-threads of Cross-linked Hyaluronic Acid Hydrogel using a Microfluidic Chip
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미세 유체 칩 기반의 히알루론산 미세 실의 제작

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Type
Academic journal
Author
Journal
The Korea Society Of Medical & Biological Engineering 의공학회지 의공학회지 제38권 제1호 KCI Accredited Journals
Published
2017.1
Pages
1 - 8 (8page)

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Micro-threads of Cross-linked Hyaluronic Acid Hydrogel using a Microfluidic Chip
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The successful synthesis of hyaluronic acid micro-threads is very promising approach for the broad application in tissue engineering such as dermal fillers. Because hyaluronic acid has the excellent biocompatibility and ability to maintain the moisture of up to several hundred times its own weight. In order to generate the hyaluronic acid micro-threads in microfluidic system, we employed two-phase flow microfluidic chip to make a rapid synthesis of the hyaluronic acid hydrogel. Hyaluronic acid was mixed with 0.02N NaOH solution and 1, 4-Butanediol diglycidyl ether (BDDE) solution and then injected into core channel. The ethanol was used for the 3-dimensional micro-thread formation in sheath channel. We manipulated the diameter of HA micro-threads using controlling of flow rates in microfluidic chip, and showed the feasibility of immobilization in HA micro-threads with florescent substances. Also, the generated HA micro-threads were evaluated and showed the suitable properties with tensile strength, bending property, and swelling profiles for dermal fillers. As a result, we suggested an innovative method for microfluidic chipbased HA micro-threads which could safely be applied as dermal filler in tissue engineering
#hyaluronic acid #4-butanediol diglycidyl ether #dermal filler #immobilization #swelling #microfluidic chip

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S. A. Zawko / 2009 / Photopatterned anisotropic swelling of dual-crosslinked hyaluronic acid hydrogels / Acta Biomaterialia 5:14~22 google schola W. J. Jeong / 2005 / Continuous fabrication of biocatalyst immobilized microparticles using photopolymerization and immiscible liquids in microfluidic systems / Langmuir 21:3738~3741 google schola Y. Jun / 2013 / Microfluidics-generated pancreatic islet microfibers for enhanced immunoprotection / Biomaterials 34:8122~8130 google schola 김영진 / 2008 / 히알루론산에 결합된 리포산 자기조립체의 제조 및 특성 / 폴리머 32(6):561~565 google schola Y. Xia / 1998 / Soft lithography / Annual review of materials science 28:153~184 google schola

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