지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 31 - 37 (7page)
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초록· 키워드
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Background: Bacteria of the Mycobacterium abscessus group are the second most com- mon pathogens responsible for lung disease caused by nontuberculous mycobacteria in Korea. There is still a lack of studies investigating the genetic mechanisms involved in M.
abscessus resistance to antibiotics other than clarithromycin. This study investigated the characteristics of drug resistance exhibited by M. abscessus clinical isolates from Korea.
Methods: We performed drug susceptibility testing for a total of 404 M. abscessus clinical strains. Subspecies were differentiated by molecular biological methods and examined for mutations in drug resistance-related genes.
Results: Of the 404 strains examined, 202 (50.00%), 199 (49.26%), and 3 (0.74%) strains were identified as M. abscessus, M. massiliense , and M. bolletii , respectively. Of the 152 clarithromycin-resistant strains, 6 possessed rrl mutations, while 4 of the 30 amikacin-resis- tant strains contained rrs mutations, and 5 of the 114 quinolone-resistant strains had gyr mutations. All mutant strains had high minimal inhibitory concentration values for the anti- biotics.
Conclusions: Our results showed the distribution of the strains with mutations in drug re- sistance-related genes was low in the M. abscessus group. Furthermore, we performed drug susceptibility testing and sequence analyses to determine the characteristics of these genes in the M. abscessus group.
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참고문헌 (28)
참고문헌 신청
Coleman K / 1994 / Bacterial resistance mechanisms as therapeutic targets / J Antimicrob Chemother 33:1091~1116
Fierro JF / 1988 / Involvement if cell impermeability in resistance to macrolides in some producer streptomycetes / J Antibiot 41:142~144
Banerjee SK / 1996 / Involvement of an efflux system in mediating high level of fluoroquinolone resistance in Mycobacterium smegmatis / Biochem Biophys Res Commun 226:362~368
Meier A / 1996 / Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population / J Infect Dis 174:354~360
Bastian S / 2011 / Assessment of clarithromycin susceptibility in strains belonging to the Mycobacterium abscessus group by erm(41) and rrl sequencing / Antimicrob Agents Chemother 55:775~781
Fierro JF / 1988 / Involvement if cell impermeability in resistance to macrolides in some producer streptomycetes / J Antibiot 41:142~144
Banerjee SK / 1996 / Involvement of an efflux system in mediating high level of fluoroquinolone resistance in Mycobacterium smegmatis / Biochem Biophys Res Commun 226:362~368
Meier A / 1996 / Molecular mechanisms of clarithromycin resistance in Mycobacterium avium: observation of multiple 23S rDNA mutations in a clonal population / J Infect Dis 174:354~360
Bastian S / 2011 / Assessment of clarithromycin susceptibility in strains belonging to the Mycobacterium abscessus group by erm(41) and rrl sequencing / Antimicrob Agents Chemother 55:775~781
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