지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 20 - 25 (6page)
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초록· 키워드
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Background: We investigated the rates of fecal transmission of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) and carbapenem-resistant Enterobacteriaceae (CRE) among patients admitted to intensive care units (ICUs).
Methods: From June to August 2012, rectal cultures were acquired from all patients at ICU admission. For patients not carrying ESBL-E or CRE at admission, follow-up cultures were performed to detect acquisition. A chromogenic assay was used to screen for ESBL-E and CRE. Bacterial species identification and antibiotic susceptibility tests were performed using the Vitek 2 system (bioMérieux, France). ESBL genotypes were determined by PCR, and clonal relatedness of the isolates was assessed by pulsed-field gel electrophoresis.
Results: Out of 347 ICU admissions, 98 patients were found to be carriers of ESBL-E (28.2%, 98/347). Follow-up cultures were acquired from 91 of the patients who tested negative for ESBL-E at admission; the acquisition rate in this group was 12.1% (11/91), although none was a nosocomial transmission. For CRE, the prevalence of fecal carriage was 0.3% (1/347), and the acquisition rate was 2.9% (4/140). None of the CRE isolates were carbapenemase-producers.
Conclusions: The high prevalence of ESBL-E carriage on admission (28.2%), coupled with rare nosocomial transmission and the very low carriage rate of CRE (0.3%), challenge the routine use of active surveillance in non-epidemic settings. Nevertheless, passive sur- veillance measures, such as rapid and accurate screening of clinical specimens, will be critical for controlling the spread of CRE.
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참고문헌 (38)
참고문헌 신청
Anderson KF / 2007 / Evaluation of methods to identify the Klebsiella pneumoniae carbapenemase in Enterobacteriaceae / J Clin Microbiol 45:2723~2725
Woodford N / 2006 / Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum β-lactamases / J Antimicrob Chemother 57:154~155
Kim J / 1998 / Survey of Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases: prevalence of SHV-12 and SHV-2a in Korea / J Clin Microbiol 36:1446~1449
Lee K / 2003 / Diversity of TEM-52 extended-spectrum beta-lactamase-producing non-typhoidal Salmonella isolates in Korea / J Antimicrob Chemother 52:493~496
Poirel L / 2001 / Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla (VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes / Antimicrob Agents Chemother 45:546~552
Woodford N / 2006 / Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum β-lactamases / J Antimicrob Chemother 57:154~155
Kim J / 1998 / Survey of Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases: prevalence of SHV-12 and SHV-2a in Korea / J Clin Microbiol 36:1446~1449
Lee K / 2003 / Diversity of TEM-52 extended-spectrum beta-lactamase-producing non-typhoidal Salmonella isolates in Korea / J Antimicrob Chemother 52:493~496
Poirel L / 2001 / Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla (VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes / Antimicrob Agents Chemother 45:546~552
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