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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 65 - 69 (5page)
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The B3 phenotype is the most common B subtype in Korea. The B305 allele (425 T>C, M142T) was first reported in 2 Chinese individuals; however, it has not yet been reported in the Koreans, and the impact of the M142T mutation on the expression of the B3 phenotype has also not been studied. To resolve an ABO discrepancy between a group O neonate and her group O father and A1B3 mother, blood samples from these individuals and other family members were referred to our laboratory for ABO gene analysis. The B305 allele was discovered in the neonate (B305/O01), her mother (A102/B305), and her maternal aunt (B305/O02), while her father was typed as O01/O02. Transient transfection experiments were performed in HeLa cells using the B305 allele synthesized by site-directed mutagenesis; flow cytometric analysis revealed that this transfect expressed 35.5% of the total B antigen produced by the B101 allele transfect. For comparison, Bx01 allele transfects were also created, and they expressed 11.4% of the total B antigen expressed on the surface of B101 transfects. These experiments demonstrate that the M142T (425 T>C) mutation is responsible for the B subtype phenotype produced by the B305 allele. (Korean J Lab Med 2010;30:65-9)
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참고문헌 (18)
참고문헌 신청
Brecher ME / 2002 / Technical manual. 14th ed / American Association of Blood Banks : 670 ~ 671
Cho D / 2004 / A novel B(var) allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele / Vox Sang 87 : 187 ~ 189
Cho D / 2005 / The genetic and phenotypic basis of blood group A subtypes in Koreans / Transfus Med 15 : 329 ~ 334
Lee SG / 2006 / Analysis of complete exons and flanking introns of ABO gene in Korean B(3) blood donors / Korean J Blood Transfus 17 : 97 ~ 105
Ogasawara K / 1996 / Molecular genetic analysis of variant phenotypes of the ABO blood group system / Blood 88 : 2732 ~ 2737
Cho D / 2004 / A novel B(var) allele (547 G>A) demonstrates differential expression depending on the co-inherited ABO allele / Vox Sang 87 : 187 ~ 189
Cho D / 2005 / The genetic and phenotypic basis of blood group A subtypes in Koreans / Transfus Med 15 : 329 ~ 334
Lee SG / 2006 / Analysis of complete exons and flanking introns of ABO gene in Korean B(3) blood donors / Korean J Blood Transfus 17 : 97 ~ 105
Ogasawara K / 1996 / Molecular genetic analysis of variant phenotypes of the ABO blood group system / Blood 88 : 2732 ~ 2737
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