지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Recent research on mild cognitive impairment (MCI) has shown that cognitive and memory decline inthis disease is accompanied by disruptive changes in the brain functional network. However, there have been nograph-theoretical studies using 11C-PIB PET data of the Alzheimer’s Disease or mild cognitive impairment. In thisstudy, we acquired 18F-FDG PET and 11C-PIB PET images of twenty-four normal aging control participants and thirtyindividuals with MCI from ADNI (Alzheimer’s Disease Neuroimaging Initiative) database. Brain networks were constructedby thresholding binary correlation matrices using graph theoretical approaches. Both normal control andMCI group showed small-world property in 11C-PIB PET images as well as 18F-FDG PET images. 11C-PIB PETimages showed significant difference between NC (normal control) and MCI over large range of sparsity values. Thisresult will enable us to further analyze the brain using established graph-theoretical approaches for 11C-PIB PET images.
목차
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참고문헌 (17)
참고문헌 신청
D. Watts. / 1998 / Collective dynamics of ‘smallworld’networks / Nature 393 : 440 ~ 442
D. Y. Lee. / 2009 / Regional pattern of white matter microstructural changes in normal aging, MCI, and AD / Neurology 73 (21) : 1722 ~ 1728
E. Braak. / 1999 / Neuropathology of Alzheimer’s disease : what is new since A. Alzheimer? / Eur. Arch. Psychiatry Clin. Neurosci. 249 (Suppl) : 14 ~ 22
E. Bullmore. / 2009 / Complex brain networks : graph theoretical analysis of structural and functional systems / Nat. Rev. Neurosci 10 (3) : 186 ~ 198
E. Seo. / 2013 / Whole-brain functional networks in cognitively normal, mild cognitive impairment, and Alzheimer’s disease / PLoS One 8 (1) : e53922 ~
D. Y. Lee. / 2009 / Regional pattern of white matter microstructural changes in normal aging, MCI, and AD / Neurology 73 (21) : 1722 ~ 1728
E. Braak. / 1999 / Neuropathology of Alzheimer’s disease : what is new since A. Alzheimer? / Eur. Arch. Psychiatry Clin. Neurosci. 249 (Suppl) : 14 ~ 22
E. Bullmore. / 2009 / Complex brain networks : graph theoretical analysis of structural and functional systems / Nat. Rev. Neurosci 10 (3) : 186 ~ 198
E. Seo. / 2013 / Whole-brain functional networks in cognitively normal, mild cognitive impairment, and Alzheimer’s disease / PLoS One 8 (1) : e53922 ~
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