지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The goal of this study is to develop test method for evaluating the drug eluting properties of drug eluting stents (DES). PBS and the detergent solutions, presented by each DES manufacturer, were used for drug release of DES coated with paclitaxel, zotarolimus and everolimus. The drugs which are coating DES were not released by PBS but released by the detergent solutions, finally paclitaxel 83.38%, zotarolimus 103.85% and everolimus 115.78%.
It seems that the use of the detergents is necessary in order to release the drugs because those drugs are extremely hydrophobic. In conclusion, using of detergent solutions presented by each manufacturer were suitable for evaluating the drug eluting property of drug eluting stent.
목차
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참고문헌 (12)
참고문헌 신청
A. Seidlitz / 2013 / In vitro Dissolution Testing of Drug-Eluting Stents / Current Pharmaceutical Biotechnology 14 : 67 ~ 75
C. P. Naseerali / 2010 / The Release Kinetics of Drug Eluting Stents Containing Sirolimus as Coated Drug : Role of Release Media / J Chromatogr B Analyt Biomed Life Sci 878 :
F. C. Nelson / 1999 / Manipulation of the C(22)-C(27)Region of Rapamycin : Stability Issues and Biological Implications / Bioorg Med Chem Lett 9 : 295 ~ 300
K. Steigerwald / 2008 / The Pre-clinical Assessment of Rapamycin-Eluting, Durable Polymer-Free Stent Coating Concepts / Biomaterials : 1 ~ 6
M. Merciadez / 2011 / A Novel Method for the Elution of Sirolimus(Rapamycin)in Drug-Eluting Stents / Dissolution Technolodies 18 : 37 ~ 42
C. P. Naseerali / 2010 / The Release Kinetics of Drug Eluting Stents Containing Sirolimus as Coated Drug : Role of Release Media / J Chromatogr B Analyt Biomed Life Sci 878 :
F. C. Nelson / 1999 / Manipulation of the C(22)-C(27)Region of Rapamycin : Stability Issues and Biological Implications / Bioorg Med Chem Lett 9 : 295 ~ 300
K. Steigerwald / 2008 / The Pre-clinical Assessment of Rapamycin-Eluting, Durable Polymer-Free Stent Coating Concepts / Biomaterials : 1 ~ 6
M. Merciadez / 2011 / A Novel Method for the Elution of Sirolimus(Rapamycin)in Drug-Eluting Stents / Dissolution Technolodies 18 : 37 ~ 42
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