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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Two polymeric prodrugs of PGE1 (prodrugs IVg and PNg) were newly synthesized. The drug conjugation proceeded in quantitative yield without decomposition of PGE1 to PGA1. With two types conjugates, PEG-PGE1 and PN-PGE1 with different spacer groups, we first discovered a possibility of slow release of PGE1 in blood circulatory system. PGE1 is conjugated with PEG and PN through the long alkylene spacers, and their availability as polymeric prodrugs is evaluated. Their drug-releasing behavior was examined both in phosphate buffer (pH=7.4) and rat plasma. Each prodrug was known to be highly stabile in the buffer solution. The drug-releasing rate became much faster in rat plasma than in the buffer solution due to the acceleration by the plasma enzymes. The drug-release was found to reach a plateau in rat plasma because the released PGE1 or its derivatives may be captured or decomposed by the plasma proteins. The slower drug-releasing rate of prodrug PNg in rat plasma is reasonably attributed to the molecular aggregation due to the hydrophobic bonding between the PGE1 moieties and spacers.
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참고문헌 (13)
참고문헌 신청
C. G. Overberger / 1979. / Graft copolymers of nucleic acid bases on polyethyleneimine Interaction of the polymers 17 : 1759 ~ 1769
C. Maltesh / 1992. / Aggregation behavior of and surface tension reduction by comb like amphiphilic polymers 8 : 1511 ~ 1513
C. W. Lee / 2001. / Synthesis and properties of multiblock copolymers consisting of oligo(L-lactic acid) and poly(oxyethylene-co- oxypropylene) with different composition 9
C. W. Lee / 2003. / In vitro biodegradability and surface properties of block copoly(ester-ether)s consisting of poly (L-lactide) and polyether 11 (1) : 42 ~ 46
C. W. Lee / 2004. / Drug-release behavior of polymeric prodrugs of ibuprofen with PEG and its derivatives as polymeric carriers 12 (1) : 71 ~ 77
C. Maltesh / 1992. / Aggregation behavior of and surface tension reduction by comb like amphiphilic polymers 8 : 1511 ~ 1513
C. W. Lee / 2001. / Synthesis and properties of multiblock copolymers consisting of oligo(L-lactic acid) and poly(oxyethylene-co- oxypropylene) with different composition 9
C. W. Lee / 2003. / In vitro biodegradability and surface properties of block copoly(ester-ether)s consisting of poly (L-lactide) and polyether 11 (1) : 42 ~ 46
C. W. Lee / 2004. / Drug-release behavior of polymeric prodrugs of ibuprofen with PEG and its derivatives as polymeric carriers 12 (1) : 71 ~ 77
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