지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 331 - 338 (8page)
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초록· 키워드
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PurposeTo evaluate the efficacy of hydromorphone-OROS (HM-OROS) in reducing sleep disturbanceand relieving cancer pain.
Materials and MethodsOne hundred twenty cancer patients with pain (numeric rating scale [NRS] ≥ 4) and sleepdisturbance (NRS ≥ 4) were evaluated. The initial HM-OROS dosing was based on previousopioid dose (HM-OROS:oral morphine=1:5). Dose adjustment of the study drug waspermitted at the investigator’s discretion. Pain intensity, number of breakthrough painepisodes, and quality of sleep were evaluated.
ResultsA total of 120 patients received at least one dose of HM-OROS; 74 of them completed thefinal assessment. Compared to the previous opioids, HM-OROS reduced the average painNRS from 5.3 to 4.1 (p < 0.01), worst pain NRS from 6.7 to 5.4 (p < 0.01), sleep disturbanceNRS from 5.9 to 4.1 (p < 0.01), incidence of breakthrough pain at night from 2.63 to 1.53times (p < 0.001), and immediate-release opioids use for the management of breakthroughpain from 0.83 to 0.39 times per night (p = 0.001). Of the 74 patients who completed thetreatment, 83.7% indicated that they preferred HM-OROS to the previous medication. Theadverse events (AEs) were somnolence, asthenia, constipation, dizziness, and nausea.
ConclusionHM-OROS was efficacious in reducing cancer pain and associated sleep disturbances. TheAEs were manageable.
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참고문헌 (23)
참고문헌 신청
Gardner-Nix J / 2010 / The role of OROS hydromorphone in the management of cancer pain / Pain Pract 10:72~77
Akechi T / 2007 / Associated and predictive factors of sleep disturbance in advanced cancer patients / Psychooncology 16 : 888 ~ 894
Bruera E / 1996 / A randomized, double-blind, double-dummy, crossover trial comparing the safety and efficacy of oral sustai
Carney S / 2011 / Differences in sleep disturbance parameters between oncology outpatients and their family caregivers / J Clin Oncol 29 : 1001 ~ 1006
Coyle N / 1990 / Character of terminal illness in the advanced cancer patient: pain and other symptoms during the last four weeks of life / J Pain Symptom Manage 5 : 83 ~ 93
Akechi T / 2007 / Associated and predictive factors of sleep disturbance in advanced cancer patients / Psychooncology 16 : 888 ~ 894
Bruera E / 1996 / A randomized, double-blind, double-dummy, crossover trial comparing the safety and efficacy of oral sustai
Carney S / 2011 / Differences in sleep disturbance parameters between oncology outpatients and their family caregivers / J Clin Oncol 29 : 1001 ~ 1006
Coyle N / 1990 / Character of terminal illness in the advanced cancer patient: pain and other symptoms during the last four weeks of life / J Pain Symptom Manage 5 : 83 ~ 93
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