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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 403 - 410 (8page)
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초록· 키워드
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PurposeThe purpose of this study was to determine the optimal biologically equivalent dose (BED)for stereotactic body radiotherapy (SBRT) by comparing local control rates in proportion tovarious total doses and fractionation schedules.
Materials and MethodsThirty-four patients with early non-small-cell lung cancer and a single metastatic lung tumorwere included in this study. Differences in local control rates were evaluated according togender, primary tumor site, response, tumor size, and BED. For comparison of BEDs, theprescribed dose for SBRT was stratified according to three groups: high (BED > 146 Gy),medium to high (BED, 106 to 146 Gy), and low to medium (BED < 106 Gy).
ResultsFor all patients, the overall local control rate was 85.3% at two years after treatment. Fivelocal recurrences were observed, and, notably, all of them were observed in the low tomedium BED group. Significantly higher local control rates were observed for patients witha complete response than for those with a partial response or stable disease (p < 0.001).
Twenty-six patients with a tumor size of < 3 cm showed no dose-response relationship inthe low to medium, medium to high, and high BED groups, whereas eight patients with atumor size of ≥ 3 cm showed a significant dose-response relationship. The observed 2-yearlocal recurrence-free survival rates in patients with a tumor size of < 3 cm and in those witha tumor size of ≥ 3 cm were 96.2% and 50.0%, respectively, which were significantlydifferent (p=0.007).
ConclusionBED > 100 Gy is required in order to achieve a > 85% local control rate regardless of tumorsize. The optimal dose for small tumors of < 3 cm appears to be within a range below 150Gy BED. Escalation of BED to high levels (> 150 Gy) may be required for patients with atumor size larger than 3 cm.
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참고문헌 (19)
참고문헌 신청
Aoki T / 2004 / Evaluation of lung injury after threedimensional conformal stereotactic radiation therapy for solitary lung tumors: CT appearance / Radiology 230 : 101 ~ 108
Baumann P / 2006 / Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer: a retrospective analysis of patients treated
Baumann P / 2009 / Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung
Chi A / 2010 / Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: clinical implications / Rad
Dunlap NE / 2010 / Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cancers treated with stereotactic body radiation therapy (SBRT) / J Thorac Cardiova
Baumann P / 2006 / Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer: a retrospective analysis of patients treated
Baumann P / 2009 / Outcome in a prospective phase II trial of medically inoperable stage I non-small-cell lung
Chi A / 2010 / Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: clinical implications / Rad
Dunlap NE / 2010 / Size matters: a comparison of T1 and T2 peripheral non-small-cell lung cancers treated with stereotactic body radiation therapy (SBRT) / J Thorac Cardiova
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