지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 176 - 180 (5page)
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초록· 키워드
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Purpose Procalcitonin (PCT) and C-reactive protein (CRP) are well known inflammatory markers. This study was designed to determine whether PCT and CRP are useful as early diagnostic markers for bacteremia in cancer patients with febrile neutropenia (FN) in the emergency department (ED).
Materials and Methods In this retrospective study, 286 episodes of FN in the ED were consecutively included between June 2009 and August 2010. From medical records, clinical characteristics including PCT and CRP were extracted and analyzed.
Results Bacteremia was identified in 38 (13.3%) of the 286 episodes. The median values of PCT (2.8ng/mL vs. 0.0 ng/mL, p=0.000) and CRP (15.9 mg/dL vs. 5.6 mg/dL, p=0.002) were significantly higher in the group with bacteremia compared to the group without bacteremia. In univariate analysis, elevated PCT (＞0.5 ng/mL) and CRP (＞10 mg/dL) as well as older age, hypotension,tachycardia, tachypnea, and high body temperature were significantly associated with bacteremia. On multivariate analysis, elevated PCT (＞0.5 ng/mL) (odds ratio [OR], 3.6; 95%confidence interval [CI], 1.4 to 9.2; p＜0.01) and tachypnea (OR, 3.4; 95% CI, 1.4 to 8.5; p＜0.01)were independent early diagnostic markers for bacteremia in FN patients. The area under the curve of PCT was 74.8% (95% CI, 65.1 to 84.6%) and that of CRP was 65.5% (95% CI, 54.8to 76.1%). With a PCT cut-off value of 0.5 ng/mL, sensitivity and specificity were 60.5% and 82.3%, respectively, while the sensitivity and specificity were 57.6% and 67.3%, respectively,with a CRP cutoff of 10 mg/dL.
Conclusion These findings suggest that PCT is a useful early diagnostic marker for the detection of bacteremia in FN at the ED and has better diagnostic value than CRP.
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참고문헌 (23)
참고문헌 신청
Adelberg DE / 2009 / Emergencies related to cancer chemotherapy and hematopoietic stem cell transplantation / Emerg Med Clin North Am 27 : 311 ~ 331
Assicot M / 1993 / High serum procalcitonin concentrations in patients with sepsis and infection / Lancet 341 : 515 ~ 518
Bossink AW / 1998 / Prediction of mortality in febrile medical patients: How useful are systemic inflammatory response syndrome and sepsis criteria / Chest 113 : 1533 ~ 1541
Bossink AW / 2001 / Prediction of shock in febrile medical patients with a clinical infection / Crit Care Med 29 : 25 ~ 31
Boussekey N / 2006 / Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia / Intensive Care Med 32 : 469 ~ 472
Assicot M / 1993 / High serum procalcitonin concentrations in patients with sepsis and infection / Lancet 341 : 515 ~ 518
Bossink AW / 1998 / Prediction of mortality in febrile medical patients: How useful are systemic inflammatory response syndrome and sepsis criteria / Chest 113 : 1533 ~ 1541
Bossink AW / 2001 / Prediction of shock in febrile medical patients with a clinical infection / Crit Care Med 29 : 25 ~ 31
Boussekey N / 2006 / Procalcitonin kinetics in the prognosis of severe community-acquired pneumonia / Intensive Care Med 32 : 469 ~ 472
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