Association of Homocysteine Levels With Blood Lead  Levels and Micronutrients in the US General Population

이유미; 이미경; 배상근; 이선화; 김선영; 이덕희

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자료유형: 학술저널

저자정보: 이유미 이미경 배상근 이선화 김선영 이덕희

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제45권 제6호

발행연도: 2012.1

수록면: 387 - 393 (7page)

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Objectives: Even though several epidemiological studies have observed positive associations between blood lead levels and homocysteine,no study has examined whether this association differs by the levels of micronutrients, such as folate, vitamin B6, and vitamin B12, which are involved in the metabolism of homocysteine. In this study, we examined the interactions between micronutrients and blood lead on homocysteine levels. Methods: This study was performed with 4089 adults aged ≥20 years old in the US general population using the National Health and Nutrition Examination Survey 2003-2004. Results: There were significant or marginally significant interactions between micronutrients and blood lead levels on mean homocysteine levels. Positive associations between blood lead and homocysteine were clearly observed among subjects with low levels of folate or low vitamin B6 (p-trend <0.01, respectively). However, in the case of vitamin B12, there was a stronger positive association between blood lead and homocysteine among subjects with high levels of vitamin B12, compared to those with low levels of vitamin B12. In fact, the levels of homocysteine were already high among subjects low in vitamin B12, irrespective of blood lead levels. When we used hyperhomocysteinemia (homocysteine>15 μmol/L) as the outcome, there were similar patterns of interaction, though pvalues for each interaction failed to reach statistical significance. Conclusions: In the current study, the association between blood lead and homocysteine differed based on the levels of folate, vitamin B6, or vitamin B12 present in the blood. It may be important to keep sufficient levels of these micronutrients to prevent the possible harmful effects of lead exposure on homocysteine levels.

#Homocysteine #Lead #Folic acid #Vitamin B6 #Vitamin B12

참고문헌 (22)

참고문헌 신청

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Centers for Disease Control and Prevention / / National Health and Nutrition Examination Survey: NHANES 2003-2004

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