정상 범위 내 혈청 GGT와 심혈관계질환의 위험요인과의 관련성

임지선; 김유진; 천병렬; 양진훈; 이덕희; 감신

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자료유형: 학술저널

저자정보: 임지선 김유진 천병렬 양진훈 이덕희 감신

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제38권 제1호

발행연도: 2005.1

수록면: 101 - 106 (6page)

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Objectives : We conducted this study to examine the association between serum GGT levels within the normal range and the risk factors of cardiovascular diseases Methods : We examined the cross-sectional association between serum GGT and the systolic and diastolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol (HDLcholesterol), and uric acid among 975 subjects that participated in the health examination of a university hospital located in Daegu city. All the patients' GGT levels were within the normal range. Results : After adjustment were made for age, body mass index (BMI), smoking status, drinking frequency, exercise frequency and coffee intake, the serum GGT level was positively associated with fasting blood glucose (p<0.01), total cholesterol (p<0.01), and triglyceride (p<0.01) in men, and it was positively associated with fasting blood glucose (p<0.01), total cholesterol (p<0.05), triglyceride (p<0.01), and uric acid (p<0.01) in women. The associations were not significantly different depending on the status of alcohol drinking or obesity, except for the associations of serum GGT with diastolic blood pressure (P for interaction=0.04) and uric acid (P for interaction=0.04) between the lean and obese subjects. Conclusions : Serum GGT levels within the normal range were positively associated with fasting blood glucose, triglyceride and uric acid in most subgroups irrespective of the drinking or obesity status. These results suggest that GGT has important clinical implications as being more than just a marker of alcohol consumption and hepatobiliary disease.

#Gamma-glutamyltransferase #Cardiovascular diseases #Drinking #Body mass index

참고문헌 (27)

참고문헌 신청

Glass GA / 1997 / Promotion of glutathione-gamma-glutamyl transpeptidasedependentlipid peroxidation by copper andceruloplasmin:the

Gray DS / 1989 / Diagnosis and prevalence of obesity 73 (1) : 1 ~ 13

Hull J / 1997 / Pulmonaryoxidative stress response in young childrenwith cystic fibrosis 52 : 557 ~ 560

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Jousilahti P / 2000 / Serumgamma-glutamyl transferase,self-reportedalcohol drinking,and the risk of stroke 31 : 1851 ~ 1855

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