예방접종력이 있는 초등학생의 홍역 항체 양성률 및 기여 요인

임현술; 배근량; 고운영; 양병국; 김영택; 이종구

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자료유형: 학술저널

저자정보: 임현술 배근량 고운영 양병국 김영택 이종구

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제38권 제4호

발행연도: 2005.1

수록면: 431 - 436 (6page)

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Objectives : We investigated the seroprevalence of the measles antibody and its attributable factors for the students who underwent routine 2-dose Schedule Era. Methods : The subjects were 996 students of the national measles seroepidemiologic study in December 2000 who had vaccination records. We conducted a questionnaire survey and we performed serologic testing for the measlesspecific IgG by using an enzyme linked immunosorbent assay. Results : The coverage for the first dose of the MMR vaccination at 12-15 months of age was 95.1% and the coverage for the second dose of MMR at 4-6 years of age was 35.0%. The proportion of subjects undergoing 2- dosesof MMR decreased as the age of the subjects increased. The seropositive rate of the measles antibody was significantly high in the second dose vaccinees (93.5% in the second dose group, 84.7% in the non-second dose group, p<0.001) and it was 72.0% in the 0-dose group, 85.4% in the 1-dose group and 93.7% in the 2-dose group (p<0.001). Two point eight percent of the subjects had a past history of measles infection. On the multiple logistic regression analysis, the first and second dose (odds ratio, 8.54; 95% CI.=3.05-23.91), the first dose (odds ratio, 3.06; 95% CI.=1.20-7.81) and the outbreak in the year 2000 (odds ratio, 1.89; 95% CI.=1.24-2.88) were the significant factors for the seropositivity. Conclusions : Maintaining high coverage with a 2-dose vaccination program would be the decisive factor to prevent an outbreak of measles and to eliminate measles in Korea.

#Measles #MMR vaccine #Vaccination #Seroprevalence

참고문헌 (14)

참고문헌 신청

/ 1987 / Measles outbreak in a fullyimmunized secondary-school population 316 : 771 ~ 774

/ 1989 / The role of secondary vaccinefailure in measles outreakes 79 : 475 ~ 478

/ 1990 / Mild measles andsecondary vaccine failure during a sustainedoutbreak in a highly vaccinated population 263 : 2467 ~ 2471

/ 1992 / Vaccine storage practice in pediatric offices 89 : 193 ~ 196

/ 1994 / Successes and failurein measles control 170 (1)

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